The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We fo...

Descripció completa

Dades bibliogràfiques
Autors principals:	Parzych, K, Saavedra-García, P, Valbuena, G, Al-Sadah, H, Robinson, M, Penfold, L, Kuzeva, D, Ruiz-Tellez, A, Loaiza, S, Holzmann, V, Caputo, V, Johnson, D, Kaiser, M, Karadimitris, A, Lam, E, Chevet, E, Feldhahn, N, Keun, H, Auner, H
Format:	Journal article
Idioma:	English
Publicat:	Springer Nature 2019

Ítems similars

Investigation of the function and behavior of p97/VCP
per: Khong, Zi Jia
Publicat: (2017)

Role of p97/VCP (Cdc48) in genome stability.
per: Vaz, B, et al.
Publicat: (2013)

Central pore residues mediate the p97/VCP activity required for ERAD.
per: DeLaBarre, B, et al.
Publicat: (2006)

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.
per: Meerang, M, et al.
Publicat: (2011)

A novel function of AAA-ATPase p97/VCP in the regulation of cell motility
per: Khong, Nicole Zi Jia, et al.
Publicat: (2021)

VCP/p97 is a proviral host factor for replication of chikungunya virus and other alphaviruses
per: Carissimo, Guillaume, et al.
Publicat: (2020)

Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication
per: Ramadan, K, et al.
Publicat: (2016)

Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine
per: Barthelme, Dominik, et al.
Publicat: (2018)

The role of p97/VCP co-factor UBXD8/FAF2 in DNA damage response
per: Kilgas, S
Publicat: (2017)

p97/VCP regulates MRE11-dependent DNA and resection and alters cellular toxicity of ionising radiation
per: Kilgas, S
Publicat: (2021)

Protein-protein interactions that mediate the role of AAA-ATPase p97/VCP/Cdc48 in protein aggregation and degradation
per: Chia, Wei Sheng
Publicat: (2013)

p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response.
per: Ramadan, K
Publicat: (2012)

The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks.
per: Torrecilla, I, et al.
Publicat: (2017)

ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain
per: Chia, Wei Sheng, et al.
Publicat: (2013)

Targeting defective proteostasis in the collagenopathies
per: Wong, Madeline Y., et al.
Publicat: (2022)

Targeting defective proteostasis in the collagenopathies
per: Wong, Madeline Y, et al.
Publicat: (2021)

Type I collagen proteostasis
per: DiChiara, Andrew Stephen
Publicat: (2018)

The C-Propeptide in Collagen Proteostasis
per: Li, Rasia (Chichi)
Publicat: (2022)

Proteostasis and diseases of the motor unit
per: Rinaldi, C, et al.
Publicat: (2016)

Control of Programmed Cell Death by GCN-1
per: Cho-Park, Yoon Andrew
Publicat: (2022)

Site-directed mutagenesis of p97/VCP to gain insight on the role of ATP binding to D1 domain affecting adaptor protein selectivity.
per: Rizal Ismail.
Publicat: (2013)

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
per: Kilgas, S, et al.
Publicat: (2021)

Chemical Biology Framework to Illuminate Proteostasis
per: Sebastian, Rebecca M, et al.
Publicat: (2021)

Host proteostasis modulates influenza evolution
per: McHugh, Sean M, et al.
Publicat: (2017)

Chemical Biology Framework to Illuminate Proteostasis
per: Sebastian, Rebecca M., et al.
Publicat: (2022)

Characterization of the ADA/GCN5 transcriptional adaptor complex
per: Horiuchi, Junjiro
Publicat: (2009)

Structural basis of RNA binding by leucine zipper GCN4
per: Nikolaev, Yaroslav, et al.
Publicat: (2013)

Mapping and Exploring the Collagen-I Proteostasis Network
per: DiChiara, Andrew Stephen, et al.
Publicat: (2018)

Chloroplast proteostasis: import, sorting, ubiquitination, and proteolysis
per: Sun, Y, et al.
Publicat: (2023)

Proteostasis and resilience in the mechanically-stressed vascular endothelium
per: Keen, A, et al.
Publicat: (2023)

Isolation of GCN5 and ADA5 in a selection for transcriptional adaptors
per: Marcus, Gregory A
Publicat: (2008)

Protein Folding, Host Cell Proteostasis, and Viral Evolution
per: Yoon, Jimin
Publicat: (2025)

GCN-RL circuit designer: Transferable transistor sizing with graph neural networks and reinforcement learning
per: Wang, H, et al.
Publicat: (2021)

Variant‐specific effects of GBA1 mutations on dopaminergic neuron proteostasis
per: Onal, G, et al.
Publicat: (2024)

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
per: Maurel, M, et al.
Publicat: (2019)

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.
per: Won, S, et al.
Publicat: (2012)

Maternal immune activation in mice disrupts proteostasis in the fetal brain
per: Kalish, Brian T., et al.
Publicat: (2022)

Maternal immune activation in mice disrupts proteostasis in the fetal brain
per: Kalish, Brian T, et al.
Publicat: (2021)

Penggunaan semula bata terbuang untuk menghasilkan paip kumbahan (VCP) : satu kajian /
per: 353524 Khairul Anuar Mohamad
Publicat: (2000)

Determining the optimal number of GAT and GCN layers for node classification in graph neural networks
per: Noor, Humaira, et al.
Publicat: (2023)