The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

VCP/p97 regulates numerous cellular functions by mediating protein degradation through its segregase activity. Its key role in governing protein homoeostasis has made VCP/p97 an appealing anticancer drug target. Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We fo...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Parzych, K, Saavedra-García, P, Valbuena, G, Al-Sadah, H, Robinson, M, Penfold, L, Kuzeva, D, Ruiz-Tellez, A, Loaiza, S, Holzmann, V, Caputo, V, Johnson, D, Kaiser, M, Karadimitris, A, Lam, E, Chevet, E, Feldhahn, N, Keun, H, Auner, H
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Springer Nature 2019

Míreanna comhchosúla

Investigation of the function and behavior of p97/VCP
de réir: Khong, Zi Jia
Foilsithe / Cruthaithe: (2017)

Role of p97/VCP (Cdc48) in genome stability.
de réir: Vaz, B, et al.
Foilsithe / Cruthaithe: (2013)

Central pore residues mediate the p97/VCP activity required for ERAD.
de réir: DeLaBarre, B, et al.
Foilsithe / Cruthaithe: (2006)

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.
de réir: Meerang, M, et al.
Foilsithe / Cruthaithe: (2011)

A novel function of AAA-ATPase p97/VCP in the regulation of cell motility
de réir: Khong, Nicole Zi Jia, et al.
Foilsithe / Cruthaithe: (2021)

VCP/p97 is a proviral host factor for replication of chikungunya virus and other alphaviruses
de réir: Carissimo, Guillaume, et al.
Foilsithe / Cruthaithe: (2020)

Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication
de réir: Ramadan, K, et al.
Foilsithe / Cruthaithe: (2016)

Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine
de réir: Barthelme, Dominik, et al.
Foilsithe / Cruthaithe: (2018)

The role of p97/VCP co-factor UBXD8/FAF2 in DNA damage response
de réir: Kilgas, S
Foilsithe / Cruthaithe: (2017)

p97/VCP regulates MRE11-dependent DNA and resection and alters cellular toxicity of ionising radiation
de réir: Kilgas, S
Foilsithe / Cruthaithe: (2021)

Protein-protein interactions that mediate the role of AAA-ATPase p97/VCP/Cdc48 in protein aggregation and degradation
de réir: Chia, Wei Sheng
Foilsithe / Cruthaithe: (2013)

p97/VCP- and Lys48-linked polyubiquitination form a new signaling pathway in DNA damage response.
de réir: Ramadan, K
Foilsithe / Cruthaithe: (2012)

The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks.
de réir: Torrecilla, I, et al.
Foilsithe / Cruthaithe: (2017)

ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain
de réir: Chia, Wei Sheng, et al.
Foilsithe / Cruthaithe: (2013)

Targeting defective proteostasis in the collagenopathies
de réir: Wong, Madeline Y., et al.
Foilsithe / Cruthaithe: (2022)

Targeting defective proteostasis in the collagenopathies
de réir: Wong, Madeline Y, et al.
Foilsithe / Cruthaithe: (2021)

Type I collagen proteostasis
de réir: DiChiara, Andrew Stephen
Foilsithe / Cruthaithe: (2018)

The C-Propeptide in Collagen Proteostasis
de réir: Li, Rasia (Chichi)
Foilsithe / Cruthaithe: (2022)

Proteostasis and diseases of the motor unit
de réir: Rinaldi, C, et al.
Foilsithe / Cruthaithe: (2016)

Control of Programmed Cell Death by GCN-1
de réir: Cho-Park, Yoon Andrew
Foilsithe / Cruthaithe: (2022)

Site-directed mutagenesis of p97/VCP to gain insight on the role of ATP binding to D1 domain affecting adaptor protein selectivity.
de réir: Rizal Ismail.
Foilsithe / Cruthaithe: (2013)

p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation
de réir: Kilgas, S, et al.
Foilsithe / Cruthaithe: (2021)

Chemical Biology Framework to Illuminate Proteostasis
de réir: Sebastian, Rebecca M, et al.
Foilsithe / Cruthaithe: (2021)

Host proteostasis modulates influenza evolution
de réir: McHugh, Sean M, et al.
Foilsithe / Cruthaithe: (2017)

Chemical Biology Framework to Illuminate Proteostasis
de réir: Sebastian, Rebecca M., et al.
Foilsithe / Cruthaithe: (2022)

Characterization of the ADA/GCN5 transcriptional adaptor complex
de réir: Horiuchi, Junjiro
Foilsithe / Cruthaithe: (2009)

Structural basis of RNA binding by leucine zipper GCN4
de réir: Nikolaev, Yaroslav, et al.
Foilsithe / Cruthaithe: (2013)

Mapping and Exploring the Collagen-I Proteostasis Network
de réir: DiChiara, Andrew Stephen, et al.
Foilsithe / Cruthaithe: (2018)

Chloroplast proteostasis: import, sorting, ubiquitination, and proteolysis
de réir: Sun, Y, et al.
Foilsithe / Cruthaithe: (2023)

Proteostasis and resilience in the mechanically-stressed vascular endothelium
de réir: Keen, A, et al.
Foilsithe / Cruthaithe: (2023)

Isolation of GCN5 and ADA5 in a selection for transcriptional adaptors
de réir: Marcus, Gregory A
Foilsithe / Cruthaithe: (2008)

Protein Folding, Host Cell Proteostasis, and Viral Evolution
de réir: Yoon, Jimin
Foilsithe / Cruthaithe: (2025)

GCN-RL circuit designer: Transferable transistor sizing with graph neural networks and reinforcement learning
de réir: Wang, H, et al.
Foilsithe / Cruthaithe: (2021)

Variant‐specific effects of GBA1 mutations on dopaminergic neuron proteostasis
de réir: Onal, G, et al.
Foilsithe / Cruthaithe: (2024)

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
de réir: Maurel, M, et al.
Foilsithe / Cruthaithe: (2019)

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.
de réir: Won, S, et al.
Foilsithe / Cruthaithe: (2012)

Maternal immune activation in mice disrupts proteostasis in the fetal brain
de réir: Kalish, Brian T., et al.
Foilsithe / Cruthaithe: (2022)

Maternal immune activation in mice disrupts proteostasis in the fetal brain
de réir: Kalish, Brian T, et al.
Foilsithe / Cruthaithe: (2021)

Determining the optimal number of GAT and GCN layers for node classification in graph neural networks
de réir: Noor, Humaira, et al.
Foilsithe / Cruthaithe: (2023)

Kajian penyusupan dan kebocoran bagi paip pembetungan VCP dalam sistem pembetungan /
de réir: 193019 Mok, Hun Yew
Foilsithe / Cruthaithe: (2005)