Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh
A cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and pl...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2023
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| _version_ | 1797110547358941184 |
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| author | Khanam, F Babu, G Rahman, N Liu, X Rajib, NH Ahmed, SU Hossen, MI Biswas, PK Kelly, S Thesis-Nyland, K Mujadidi, Y McMillan, NAJ Pollard, AJ Clemens, JD Qadri, F |
| author_facet | Khanam, F Babu, G Rahman, N Liu, X Rajib, NH Ahmed, SU Hossen, MI Biswas, PK Kelly, S Thesis-Nyland, K Mujadidi, Y McMillan, NAJ Pollard, AJ Clemens, JD Qadri, F |
| author_sort | Khanam, F |
| collection | OXFORD |
| description | A cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of protection, analyzing the antibodies of children who received Vi-TT provides evidence that may later be useful in predicting population protection. |
| first_indexed | 2024-03-07T07:56:19Z |
| format | Journal article |
| id | oxford-uuid:9ac7c463-80ef-4cc3-bab5-98e05d387498 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:56:19Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:9ac7c463-80ef-4cc3-bab5-98e05d3874982023-08-17T10:58:06ZImmune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in BangladeshJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9ac7c463-80ef-4cc3-bab5-98e05d387498EnglishSymplectic ElementsElsevier2023Khanam, FBabu, GRahman, NLiu, XRajib, NHAhmed, SUHossen, MIBiswas, PKKelly, SThesis-Nyland, KMujadidi, YMcMillan, NAJPollard, AJClemens, JDQadri, FA cluster-randomized trial of Vi-TT was conducted in Dhaka, Bangladesh, using JE vaccine as the control. A subset of 1,500 children were randomly selected on 2:1 basis (Vi-TT vs JE) to assess immune response. Blood was collected before vaccination, and on days 28, 545 and 730 post-vaccination and plasma anti-Vi-IgG response was measured. A robust, persistent antibody response was induced after single dose of Vi-TT, even after 2 years of vaccination. While there is no accepted serological antibody threshold of protection, analyzing the antibodies of children who received Vi-TT provides evidence that may later be useful in predicting population protection. |
| spellingShingle | Khanam, F Babu, G Rahman, N Liu, X Rajib, NH Ahmed, SU Hossen, MI Biswas, PK Kelly, S Thesis-Nyland, K Mujadidi, Y McMillan, NAJ Pollard, AJ Clemens, JD Qadri, F Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh |
| title | Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh |
| title_full | Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh |
| title_fullStr | Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh |
| title_full_unstemmed | Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh |
| title_short | Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh |
| title_sort | immune responses in children after vaccination with a typhoid vi tetanus toxoid conjugate vaccine in bangladesh |
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