The use of monoclonal antibodies to achieve immunological tolerance.
Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming is accompanied by potent T-cell dependent, 'in...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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| _version_ | 1797084271964323840 |
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| author | Waldmann, H Cobbold, S |
| author_facet | Waldmann, H Cobbold, S |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | Monoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms. |
| first_indexed | 2024-03-07T01:53:08Z |
| format | Journal article |
| id | oxford-uuid:9acd08e1-33e9-433b-a292-f28e8b4ba29f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:53:08Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:9acd08e1-33e9-433b-a292-f28e8b4ba29f2022-03-27T00:23:51ZThe use of monoclonal antibodies to achieve immunological tolerance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9acd08e1-33e9-433b-a292-f28e8b4ba29fEnglishSymplectic Elements at Oxford1993Waldmann, HCobbold, SMonoclonal antibodies are potentially useful immunosuppressive agents. Short courses of CD4/CD8 monoclonal antibody can be used to guide the immune system of experimental animals to accept organ grafts and to arrest autoimmunity. This reprogramming is accompanied by potent T-cell dependent, 'infectious' regulatory mechanisms. A goal for therapeutic immunosuppression should be to understand and harness these innate immunoregulatory mechanisms. |
| spellingShingle | Waldmann, H Cobbold, S The use of monoclonal antibodies to achieve immunological tolerance. |
| title | The use of monoclonal antibodies to achieve immunological tolerance. |
| title_full | The use of monoclonal antibodies to achieve immunological tolerance. |
| title_fullStr | The use of monoclonal antibodies to achieve immunological tolerance. |
| title_full_unstemmed | The use of monoclonal antibodies to achieve immunological tolerance. |
| title_short | The use of monoclonal antibodies to achieve immunological tolerance. |
| title_sort | use of monoclonal antibodies to achieve immunological tolerance |
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