Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion.
The hematological and clinical features of 26 patients with myelodysplasia and a chromosome 5q deletion in the bone marrow are presented. We have examined the relationship of French-American-British Co-operative Group (FAB) 1982 classification and bone marrow karyotype at diagnosis with patient outc...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1995
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| _version_ | 1797084292401070080 |
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| author | Lewis, S Oscier, D Boultwood, J Ross, F Fitchett, M Rack, K Abrahamson, G Buckle, V Wainscoat, J |
| author_facet | Lewis, S Oscier, D Boultwood, J Ross, F Fitchett, M Rack, K Abrahamson, G Buckle, V Wainscoat, J |
| author_sort | Lewis, S |
| collection | OXFORD |
| description | The hematological and clinical features of 26 patients with myelodysplasia and a chromosome 5q deletion in the bone marrow are presented. We have examined the relationship of French-American-British Co-operative Group (FAB) 1982 classification and bone marrow karyotype at diagnosis with patient outcome and the presence or absence of the classical features of the 5q-syndrome. Those patients classified as refractory anemia (RA) with no additional karyotypic abnormalities have the typical features of the 5q-syndrome and a good prognosis. None of the patients in this group transformed to acute leukemia during the period of follow-up. Patients with either refractory anemia and excess blasts (RAEB) or additional karyotypic abnormalities show many of the hematologic features of the 5q-syndrome but do not share the good prognosis. We conclude that the 5q-syndrome may be best defined as primary MDS of the FAB type RA with a 5q deletion as the sole karyotypic abnormality. This simple definition will distinguish patients with a good prognosis and all the classical features of the 5q-syndrome. |
| first_indexed | 2024-03-07T01:53:26Z |
| format | Journal article |
| id | oxford-uuid:9ae9e611-be73-452e-b036-20f5f3746d1e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:53:26Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:9ae9e611-be73-452e-b036-20f5f3746d1e2022-03-27T00:24:45ZHematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9ae9e611-be73-452e-b036-20f5f3746d1eEnglishSymplectic Elements at Oxford1995Lewis, SOscier, DBoultwood, JRoss, FFitchett, MRack, KAbrahamson, GBuckle, VWainscoat, JThe hematological and clinical features of 26 patients with myelodysplasia and a chromosome 5q deletion in the bone marrow are presented. We have examined the relationship of French-American-British Co-operative Group (FAB) 1982 classification and bone marrow karyotype at diagnosis with patient outcome and the presence or absence of the classical features of the 5q-syndrome. Those patients classified as refractory anemia (RA) with no additional karyotypic abnormalities have the typical features of the 5q-syndrome and a good prognosis. None of the patients in this group transformed to acute leukemia during the period of follow-up. Patients with either refractory anemia and excess blasts (RAEB) or additional karyotypic abnormalities show many of the hematologic features of the 5q-syndrome but do not share the good prognosis. We conclude that the 5q-syndrome may be best defined as primary MDS of the FAB type RA with a 5q deletion as the sole karyotypic abnormality. This simple definition will distinguish patients with a good prognosis and all the classical features of the 5q-syndrome. |
| spellingShingle | Lewis, S Oscier, D Boultwood, J Ross, F Fitchett, M Rack, K Abrahamson, G Buckle, V Wainscoat, J Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion. |
| title | Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion. |
| title_full | Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion. |
| title_fullStr | Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion. |
| title_full_unstemmed | Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion. |
| title_short | Hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion. |
| title_sort | hematological features of patients with myelodysplastic syndromes associated with a chromosome 5q deletion |
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