Cells of the immune system orchestrate changes in bone cell function
There is a complex interplay between the cells of the immune system and bone. Immune cells, such as T and NK cells, are able to enhance osteoclast formation via the production of RANKL. Yet there is increasing evidence to show that during the resolution of inflammation or as a consequence of increas...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797084298109517824 |
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| author | Wythe, SE Nicolaidou, V Horwood, N |
| author_facet | Wythe, SE Nicolaidou, V Horwood, N |
| author_sort | Wythe, SE |
| collection | OXFORD |
| description | There is a complex interplay between the cells of the immune system and bone. Immune cells, such as T and NK cells, are able to enhance osteoclast formation via the production of RANKL. Yet there is increasing evidence to show that during the resolution of inflammation or as a consequence of increased osteoclastogenesis there is an anabolic response via the formation of more osteoblasts. Furthermore, osteoblasts themselves are involved in the control of immune cell function, thus promoting the resolution of inflammation. Hence, the concept of "coupling" - how bone formation is linked to resorption - needs to be more inclusive rather than restricting our focus to osteoblast-osteoclast interactions as in a whole organism these cells are never in isolation. This review will investigate the role of immune cells in normal bone homeostasis and in inflammatory diseases where the balance between resorption and formation is lost. © 2013 Springer Science+Business Media New York. |
| first_indexed | 2024-03-07T01:53:31Z |
| format | Journal article |
| id | oxford-uuid:9af05fad-da0b-416c-9c46-5b8dc694e1e8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:53:31Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:9af05fad-da0b-416c-9c46-5b8dc694e1e82022-03-27T00:24:58ZCells of the immune system orchestrate changes in bone cell functionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9af05fad-da0b-416c-9c46-5b8dc694e1e8EnglishSymplectic Elements at Oxford2014Wythe, SENicolaidou, VHorwood, NThere is a complex interplay between the cells of the immune system and bone. Immune cells, such as T and NK cells, are able to enhance osteoclast formation via the production of RANKL. Yet there is increasing evidence to show that during the resolution of inflammation or as a consequence of increased osteoclastogenesis there is an anabolic response via the formation of more osteoblasts. Furthermore, osteoblasts themselves are involved in the control of immune cell function, thus promoting the resolution of inflammation. Hence, the concept of "coupling" - how bone formation is linked to resorption - needs to be more inclusive rather than restricting our focus to osteoblast-osteoclast interactions as in a whole organism these cells are never in isolation. This review will investigate the role of immune cells in normal bone homeostasis and in inflammatory diseases where the balance between resorption and formation is lost. © 2013 Springer Science+Business Media New York. |
| spellingShingle | Wythe, SE Nicolaidou, V Horwood, N Cells of the immune system orchestrate changes in bone cell function |
| title | Cells of the immune system orchestrate changes in bone cell function |
| title_full | Cells of the immune system orchestrate changes in bone cell function |
| title_fullStr | Cells of the immune system orchestrate changes in bone cell function |
| title_full_unstemmed | Cells of the immune system orchestrate changes in bone cell function |
| title_short | Cells of the immune system orchestrate changes in bone cell function |
| title_sort | cells of the immune system orchestrate changes in bone cell function |
| work_keys_str_mv | AT wythese cellsoftheimmunesystemorchestratechangesinbonecellfunction AT nicolaidouv cellsoftheimmunesystemorchestratechangesinbonecellfunction AT horwoodn cellsoftheimmunesystemorchestratechangesinbonecellfunction |