The Kir6.2-F333I mutation differentially modulates K ATP channels composed of SUR1 and SUR2 subunits
Mutations in Kir6.2, the pore-forming subunit of the K ATP channel, that reduce the ability of ATP to block the channel cause neonatal diabetes. The stimulatory effect of MgATP mediated by the regulatory sulphonylurea receptor (SUR) subunit of the channel may also be modified. We compared the effect...
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| Format: | Journal article |
| Language: | English |
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Blackwell Publishing
2007
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