Impairment of DNA methylation maintenance is the main cause of global demethylation in naive embryonic stem cells
Global demethylation is part of a conserved program of epigenetic reprogramming to naive pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to naive hypomethylated ones (serum-to-2i) is a valuable model system for epigenetic reprogramming. We present a mathematical...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| 格式: | Journal article |
| 出版: |
Cell Press
2016
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