Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

T helper (Th) cells are CD4+ effector T cells that play a critical role in immunity by shaping the inflammatory cytokine environment in a variety of physiological and pathological situations. Using a combined chemico-genetic approach, we identify histone H3K27 demethylases KDM6A and KDM6B as central...

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Bibliographic Details
Main Authors: Cribbs, AP, Terlecki-Zaniewicz, S, Philpott, M, Baardman, J, Ahern, D, Lindow, M, Obad, S, Oerum, H, Sampey, B, Mander, PK, Penn, H, Wordsworth, P, Bowness, P, De Winther, M, Prinjha, RK, Feldmann, M, Oppermann, U
Format: Journal article
Language:English
Published: National Academy of Sciences 2020

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