Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes.
Genetic modification of mosquitoes offers exciting possibilities for controlling malaria, but success will depend on how transformation affects the fitness of modified insects. The expression of an exogenous gene, the mutations caused by its insertion, and inbreeding while transformed lines are esta...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797084466537037824 |
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| author | Catteruccia, F Godfray, H Crisanti, A |
| author_facet | Catteruccia, F Godfray, H Crisanti, A |
| author_sort | Catteruccia, F |
| collection | OXFORD |
| description | Genetic modification of mosquitoes offers exciting possibilities for controlling malaria, but success will depend on how transformation affects the fitness of modified insects. The expression of an exogenous gene, the mutations caused by its insertion, and inbreeding while transformed lines are established can all lead to reductions in fitness. Factors influencing fitness were investigated in cage experiments with four lines of transgenic Anopheles stephensi, a vector species of human malaria. The results indicate direct costs of the introduced transgene in at least three out of the four lines, as well as an apparent cost of the inbreeding involved in making transgenic homozygotes. |
| first_indexed | 2024-03-07T01:55:38Z |
| format | Journal article |
| id | oxford-uuid:9b9b474b-7df1-4dee-965f-a22f26db1024 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:55:38Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:9b9b474b-7df1-4dee-965f-a22f26db10242022-03-27T00:29:59ZImpact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9b9b474b-7df1-4dee-965f-a22f26db1024EnglishSymplectic Elements at Oxford2003Catteruccia, FGodfray, HCrisanti, AGenetic modification of mosquitoes offers exciting possibilities for controlling malaria, but success will depend on how transformation affects the fitness of modified insects. The expression of an exogenous gene, the mutations caused by its insertion, and inbreeding while transformed lines are established can all lead to reductions in fitness. Factors influencing fitness were investigated in cage experiments with four lines of transgenic Anopheles stephensi, a vector species of human malaria. The results indicate direct costs of the introduced transgene in at least three out of the four lines, as well as an apparent cost of the inbreeding involved in making transgenic homozygotes. |
| spellingShingle | Catteruccia, F Godfray, H Crisanti, A Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes. |
| title | Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes. |
| title_full | Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes. |
| title_fullStr | Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes. |
| title_full_unstemmed | Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes. |
| title_short | Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes. |
| title_sort | impact of genetic manipulation on the fitness of anopheles stephensi mosquitoes |
| work_keys_str_mv | AT catterucciaf impactofgeneticmanipulationonthefitnessofanophelesstephensimosquitoes AT godfrayh impactofgeneticmanipulationonthefitnessofanophelesstephensimosquitoes AT crisantia impactofgeneticmanipulationonthefitnessofanophelesstephensimosquitoes |