Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes.
OBJECTIVE: To examine whether index scores based on the EQ-5D, a 5-item generic health status measure, are an independent predictor of vascular events, other major complications and mortality in people with type 2 diabetes and to quantify the relationship between these scores and future survival. S...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1826287249997692928 |
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| author | Clarke, P Hayes, A Glasziou, P Scott, R Simes, J Keech, A |
| author_facet | Clarke, P Hayes, A Glasziou, P Scott, R Simes, J Keech, A |
| author_sort | Clarke, P |
| collection | OXFORD |
| description | OBJECTIVE: To examine whether index scores based on the EQ-5D, a 5-item generic health status measure, are an independent predictor of vascular events, other major complications and mortality in people with type 2 diabetes and to quantify the relationship between these scores and future survival. SUBJECTS: Five-year cohort study involving 7348 patients with type 2 diabetes, aged between 50-75 years who had been recruited to the FIELD (Fenofibrate Intervention and Event Lowering in Diabetes) study from Australia and New Zealand. MEASURES: Multivariate Cox proportional hazard regression models were used to estimate the hazard ratio associated with index scores derived from the EQ-5D on: (1) cardiovascular events (including coronary heart disease event, stroke, hospitalization for angina, or cardiovascular death); (2) other major diabetes-related complications (heart failure, amputation, renal dialysis, and lower extremity ulcer); and (3) death from any cause. Life table methods were used to derive expected survival for patients with different index scores. RESULTS: After adjusting for standard risk factors, a 0.1 higher index score (derived from the UK algorithm) was associated with an additional 7% (95% CI: 4-11%) lower risk of vascular events, a 13% (95% CI: 9-17%) lower risk of complications, and up to 14% (95% CI: 8-19%) lower rate of all-cause mortality. CONCLUSIONS: Index scores derived from the EQ-5D are an independent predictor of the risk of mortality, future vascular events, and other complications in people with type 2 diabetes. This should be taken into account when extrapolating health outcomes such as quality-adjusted life years (QALYs). |
| first_indexed | 2024-03-07T01:55:49Z |
| format | Journal article |
| id | oxford-uuid:9bacff40-b396-4ab3-876c-b76a7225027c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:55:49Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:9bacff40-b396-4ab3-876c-b76a7225027c2022-03-27T00:30:26ZUsing the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9bacff40-b396-4ab3-876c-b76a7225027cEnglishSymplectic Elements at Oxford2009Clarke, PHayes, AGlasziou, PScott, RSimes, JKeech, A OBJECTIVE: To examine whether index scores based on the EQ-5D, a 5-item generic health status measure, are an independent predictor of vascular events, other major complications and mortality in people with type 2 diabetes and to quantify the relationship between these scores and future survival. SUBJECTS: Five-year cohort study involving 7348 patients with type 2 diabetes, aged between 50-75 years who had been recruited to the FIELD (Fenofibrate Intervention and Event Lowering in Diabetes) study from Australia and New Zealand. MEASURES: Multivariate Cox proportional hazard regression models were used to estimate the hazard ratio associated with index scores derived from the EQ-5D on: (1) cardiovascular events (including coronary heart disease event, stroke, hospitalization for angina, or cardiovascular death); (2) other major diabetes-related complications (heart failure, amputation, renal dialysis, and lower extremity ulcer); and (3) death from any cause. Life table methods were used to derive expected survival for patients with different index scores. RESULTS: After adjusting for standard risk factors, a 0.1 higher index score (derived from the UK algorithm) was associated with an additional 7% (95% CI: 4-11%) lower risk of vascular events, a 13% (95% CI: 9-17%) lower risk of complications, and up to 14% (95% CI: 8-19%) lower rate of all-cause mortality. CONCLUSIONS: Index scores derived from the EQ-5D are an independent predictor of the risk of mortality, future vascular events, and other complications in people with type 2 diabetes. This should be taken into account when extrapolating health outcomes such as quality-adjusted life years (QALYs). |
| spellingShingle | Clarke, P Hayes, A Glasziou, P Scott, R Simes, J Keech, A Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes. |
| title | Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes. |
| title_full | Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes. |
| title_fullStr | Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes. |
| title_full_unstemmed | Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes. |
| title_short | Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes. |
| title_sort | using the eq 5d index score as a predictor of outcomes in patients with type 2 diabetes |
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