Asymmetric synthesis of the marine alkaloid (-)-(S)-nakinadine C

The first asymmetric synthesis of the marine alkaloid (-)-(S)-nakinadine C is described. This synthesis employs the conjugate addition of lithium dibenzylamide to an N-α-phenylacryloyl SuperQuat derivative followed by diastereoselective protonation of the intermediate enolate using 2-pyridone as the...

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Hlavní autoři: Davies, S, Roberts, P, Shah, R, Thomson, J
Médium: Journal article
Jazyk:English
Vydáno: 2013