Cyclobutanone mimics of intermediates in metallo-β-lactamase catalysis.

Cyclobutanone mimics of intermediates in metallo-β-lactamase catalysis.

The most important resistance mechanism to β-lactam antibiotics involves hydrolysis by two β-lactamase categories: the nucleophilic serine (SBL) and the metallo- (MBL) β-lactamases. Cyclobutanones are hydrolytically stable β-lactam analogues with potential to inhibit both SBLs and MBLs. We describe...

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Bibliographic Details
Main Authors:	Abboud, M, Kosmopoulou, M, Krismanich, A, Johnson, J, Hinchliffe, P, Brem, J, Claridge, T, Spencer, J, Schofield, C, Dmitrienko, G
Format:	Journal article
Language:	English
Published:	Wiley 2017

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