A predictive approach to identify clinical state, emotional valence and pharmacologic effect in human task-based fMRI data

Clinically approved antidepressants modulate the brain’s emotional valence circuits, suggesting that the response of these circuits could serve as a biomarker for screening candidate antidepressant drugs. Here, we apply a cross-validated predictive model to classify clinical state, emotional valence...

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Bibliographic Details
Main Authors: Barron, D, Salehi, M, Browning, M, Harmer, C, Constable, T, Duff, E
Format: Conference item
Published: Elsevier 2018
Description
Summary:Clinically approved antidepressants modulate the brain’s emotional valence circuits, suggesting that the response of these circuits could serve as a biomarker for screening candidate antidepressant drugs. Here, we apply a cross-validated predictive model to classify clinical state, emotional valence, and pharmacologic effect across eight task-based fMRI studies (n=306) of the effect of antidepressant administration on emotional face processing.