T cell-dendritic cell immunological synapses.
Dendritic cells (DCs) are myeloid lineage cells that are imprinted by their environment and that mature in response to microbial products. A crucial role of the DC is to impart this context-specific information to T cells as well as to present self and foreign MHC-peptide complexes through formation...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797084566881566720 |
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| author | Dustin, M Tseng, S Varma, R Campi, G |
| author_facet | Dustin, M Tseng, S Varma, R Campi, G |
| author_sort | Dustin, M |
| collection | OXFORD |
| description | Dendritic cells (DCs) are myeloid lineage cells that are imprinted by their environment and that mature in response to microbial products. A crucial role of the DC is to impart this context-specific information to T cells as well as to present self and foreign MHC-peptide complexes through formation of an immunological synapse. The structure of the T cell-DC immunological synapse departs from the canonical structure formed with B cells or with supported planar bilayers in that it has multiple foci of T-cell receptor interactions rather than a central focus. Recent studies on model systems provide insight into the mechanisms and biological consequences of the unique T cell-DC synaptic patterns. |
| first_indexed | 2024-03-07T01:56:56Z |
| format | Journal article |
| id | oxford-uuid:9c05863e-ee1c-4c5e-9610-044413c75b55 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:56:56Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:9c05863e-ee1c-4c5e-9610-044413c75b552022-03-27T00:33:12ZT cell-dendritic cell immunological synapses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9c05863e-ee1c-4c5e-9610-044413c75b55EnglishSymplectic Elements at Oxford2006Dustin, MTseng, SVarma, RCampi, GDendritic cells (DCs) are myeloid lineage cells that are imprinted by their environment and that mature in response to microbial products. A crucial role of the DC is to impart this context-specific information to T cells as well as to present self and foreign MHC-peptide complexes through formation of an immunological synapse. The structure of the T cell-DC immunological synapse departs from the canonical structure formed with B cells or with supported planar bilayers in that it has multiple foci of T-cell receptor interactions rather than a central focus. Recent studies on model systems provide insight into the mechanisms and biological consequences of the unique T cell-DC synaptic patterns. |
| spellingShingle | Dustin, M Tseng, S Varma, R Campi, G T cell-dendritic cell immunological synapses. |
| title | T cell-dendritic cell immunological synapses. |
| title_full | T cell-dendritic cell immunological synapses. |
| title_fullStr | T cell-dendritic cell immunological synapses. |
| title_full_unstemmed | T cell-dendritic cell immunological synapses. |
| title_short | T cell-dendritic cell immunological synapses. |
| title_sort | t cell dendritic cell immunological synapses |
| work_keys_str_mv | AT dustinm tcelldendriticcellimmunologicalsynapses AT tsengs tcelldendriticcellimmunologicalsynapses AT varmar tcelldendriticcellimmunologicalsynapses AT campig tcelldendriticcellimmunologicalsynapses |