Functional analysis of cancer-causing FBXW7 mutations
<p>FBXW7 encodes the substrate recognition component of an SCF E3 ubiquitin ligase complex. This complex regulates the degradation of multiple targets, such as Notch1, c-Jun, c-Myc and cyclin E, that function in critical developmental and cancer pathways. FBXW7 mutations are found in cancers o...
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| 格式: | Thesis |
| 语言: | English |
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2012
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