Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke.

Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients w...

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Bibliografiska uppgifter
Huvudupphovsmän: Hill, MD, Barber, P, Takahashi, J, Demchuk, A, Feasby, T, Buchan, A
Materialtyp: Journal article
Språk:English
Publicerad: 2000
Beskrivning
Sammanfattning:Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.