What evidence is there for the homology of protein-protein interactions?

The notion that sequence homology implies functional similarity underlies much of computational biology. In the case of protein-protein interactions, an interaction can be inferred between two proteins on the basis that sequence-similar proteins have been observed to interact. The use of transferred...

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Bibliographic Details
Main Authors: Lewis, A, Jones, N, Porter, M, Deane, C
Format: Journal article
Language:English
Published: Public Library of Science 2012