Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help.
There is now considerable evidence suggesting that CD8(+) T cells are able to generate effector but not functional memory T cells following pathogenic infections in the absence of CD4(+) T cells. We show that following transplantation of allogeneic skin, in the absence of CD4(+) T cells, CD8(+) T ce...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797084701583736832 |
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| author | Jones, N Carvalho-Gaspar, M Luo, S Brook, M Martin, L Wood, K |
| author_facet | Jones, N Carvalho-Gaspar, M Luo, S Brook, M Martin, L Wood, K |
| author_sort | Jones, N |
| collection | OXFORD |
| description | There is now considerable evidence suggesting that CD8(+) T cells are able to generate effector but not functional memory T cells following pathogenic infections in the absence of CD4(+) T cells. We show that following transplantation of allogeneic skin, in the absence of CD4(+) T cells, CD8(+) T cells become activated, proliferate, and expand exclusively in the draining lymph nodes and are able to infiltrate and reject skin allografts. CD44(+)CD8(+) T cells isolated 100 days after transplantation rapidly produce IFN-gamma following restimulation with alloantigen in vitro. In vivo CD44(+)CD8(+) T cells rejected donor-type skin allografts more rapidly than naive CD8(+) T cells demonstrating the ability of these putative memory T cells to mount an effective recall response in vivo. These data form the first direct demonstration that CD8(+) T cells are able to generate memory as well as effector cells in response to alloantigen during rejection in the complete absence of CD4(+) T cells. These data have important implications for the design of therapies to combat rejection and serve to reinforce the view that CD8(+) T cell responses to allografts require manipulation in addition to CD4(+) T cell responses to completely prevent the rejection of foreign organ transplants. |
| first_indexed | 2024-03-07T01:58:41Z |
| format | Journal article |
| id | oxford-uuid:9c9d7426-c7ab-4e98-be49-516f424d1856 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:58:41Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:9c9d7426-c7ab-4e98-be49-516f424d18562022-03-27T00:37:09ZEffector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9c9d7426-c7ab-4e98-be49-516f424d1856EnglishSymplectic Elements at Oxford2006Jones, NCarvalho-Gaspar, MLuo, SBrook, MMartin, LWood, KThere is now considerable evidence suggesting that CD8(+) T cells are able to generate effector but not functional memory T cells following pathogenic infections in the absence of CD4(+) T cells. We show that following transplantation of allogeneic skin, in the absence of CD4(+) T cells, CD8(+) T cells become activated, proliferate, and expand exclusively in the draining lymph nodes and are able to infiltrate and reject skin allografts. CD44(+)CD8(+) T cells isolated 100 days after transplantation rapidly produce IFN-gamma following restimulation with alloantigen in vitro. In vivo CD44(+)CD8(+) T cells rejected donor-type skin allografts more rapidly than naive CD8(+) T cells demonstrating the ability of these putative memory T cells to mount an effective recall response in vivo. These data form the first direct demonstration that CD8(+) T cells are able to generate memory as well as effector cells in response to alloantigen during rejection in the complete absence of CD4(+) T cells. These data have important implications for the design of therapies to combat rejection and serve to reinforce the view that CD8(+) T cell responses to allografts require manipulation in addition to CD4(+) T cell responses to completely prevent the rejection of foreign organ transplants. |
| spellingShingle | Jones, N Carvalho-Gaspar, M Luo, S Brook, M Martin, L Wood, K Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help. |
| title | Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help. |
| title_full | Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help. |
| title_fullStr | Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help. |
| title_full_unstemmed | Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help. |
| title_short | Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help. |
| title_sort | effector and memory cd8 t cells can be generated in response to alloantigen independently of cd4 t cell help |
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