Acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure.
BACKGROUND: Evidence suggests that distensibility of the aorta is decreased in patients with end-stage renal failure, while the underlying mechanisms are unclear. HYPOTHESIS: The purpose of the study was to evaluate the distensibility of the aorta in patients at the end stage of chronic renal failu...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1826287478885056512 |
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| author | Soubassi, L Tousoulis, D Antoniades, C Lambrou, S Aggeli, C Chaniotis, D Soubassi, S Pitsavos, C Stefanadis, C Soubassis, P Toutouzas, P |
| author_facet | Soubassi, L Tousoulis, D Antoniades, C Lambrou, S Aggeli, C Chaniotis, D Soubassi, S Pitsavos, C Stefanadis, C Soubassis, P Toutouzas, P |
| author_sort | Soubassi, L |
| collection | OXFORD |
| description | BACKGROUND: Evidence suggests that distensibility of the aorta is decreased in patients with end-stage renal failure, while the underlying mechanisms are unclear. HYPOTHESIS: The purpose of the study was to evaluate the distensibility of the aorta in patients at the end stage of chronic renal failure before and after hemodialysis (HD). METHODS: The diameter of the ascending aorta and distensibility were assessed in 48 patients on HD (31 men, 17 women, aged 45+/-14 years) and in 27 normal subjects (17 men, 10 women, aged 44+/-14 years). The diameter of the aorta was evaluated by M-mode in the parasternal long-axis view. RESULTS: Aortic distensibility was significantly lower in patients on HD before HD (1.9+/-0.7 cm(2) x dyn(-1) x 10(-6)) than in normal control subjects (3.8+/-1.0 cm(2) x dyn(-1) X 10(-6), p< 0.0001). After dialysis, it increased to 2.6+/-1.2 (p < 0.05 compared with baseline, p < 0.001 compared with controls). The change of aortic distensibility correlated with age (R(2) = 0.629 p < 0.001) and ultrafiltration volume (R(2) = 0.168, p < 0.01). CONCLUSIONS: Aortic distensibility in patients with end-stage renal disease is significantly lower than in normal subjects, and it is significantly improved after HD. |
| first_indexed | 2024-03-07T01:59:17Z |
| format | Journal article |
| id | oxford-uuid:9cc970e3-56d0-40d2-bcb2-853275034ec8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:59:17Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:9cc970e3-56d0-40d2-bcb2-853275034ec82022-03-27T00:38:37ZAcute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9cc970e3-56d0-40d2-bcb2-853275034ec8EnglishSymplectic Elements at Oxford2006Soubassi, LTousoulis, DAntoniades, CLambrou, SAggeli, CChaniotis, DSoubassi, SPitsavos, CStefanadis, CSoubassis, PToutouzas, P BACKGROUND: Evidence suggests that distensibility of the aorta is decreased in patients with end-stage renal failure, while the underlying mechanisms are unclear. HYPOTHESIS: The purpose of the study was to evaluate the distensibility of the aorta in patients at the end stage of chronic renal failure before and after hemodialysis (HD). METHODS: The diameter of the ascending aorta and distensibility were assessed in 48 patients on HD (31 men, 17 women, aged 45+/-14 years) and in 27 normal subjects (17 men, 10 women, aged 44+/-14 years). The diameter of the aorta was evaluated by M-mode in the parasternal long-axis view. RESULTS: Aortic distensibility was significantly lower in patients on HD before HD (1.9+/-0.7 cm(2) x dyn(-1) x 10(-6)) than in normal control subjects (3.8+/-1.0 cm(2) x dyn(-1) X 10(-6), p< 0.0001). After dialysis, it increased to 2.6+/-1.2 (p < 0.05 compared with baseline, p < 0.001 compared with controls). The change of aortic distensibility correlated with age (R(2) = 0.629 p < 0.001) and ultrafiltration volume (R(2) = 0.168, p < 0.01). CONCLUSIONS: Aortic distensibility in patients with end-stage renal disease is significantly lower than in normal subjects, and it is significantly improved after HD. |
| spellingShingle | Soubassi, L Tousoulis, D Antoniades, C Lambrou, S Aggeli, C Chaniotis, D Soubassi, S Pitsavos, C Stefanadis, C Soubassis, P Toutouzas, P Acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure. |
| title | Acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure. |
| title_full | Acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure. |
| title_fullStr | Acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure. |
| title_full_unstemmed | Acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure. |
| title_short | Acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure. |
| title_sort | acute improvement of aortic mechanics following hemodialysis in patients with chronic renal failure |
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