Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.

Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Julg, B, Williams, K, Reddy, S, Bishop, K, Qi, Y, Carrington, M, Goulder, P, Ndung'u, T, Walker, B
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2010
Disgrifiad
Crynodeb:Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13) or narrow (