Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.
Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined...
| Hlavní autoři: | , , , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
2010
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| _version_ | 1826287500137594880 |
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| author | Julg, B Williams, K Reddy, S Bishop, K Qi, Y Carrington, M Goulder, P Ndung'u, T Walker, B |
| author_facet | Julg, B Williams, K Reddy, S Bishop, K Qi, Y Carrington, M Goulder, P Ndung'u, T Walker, B |
| author_sort | Julg, B |
| collection | OXFORD |
| description | Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13) or narrow ( |
| first_indexed | 2024-03-07T01:59:36Z |
| format | Journal article |
| id | oxford-uuid:9ce461ab-97fb-40a4-bc3e-bdf9d12e9aa0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:59:36Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:9ce461ab-97fb-40a4-bc3e-bdf9d12e9aa02022-03-27T00:39:20ZEnhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9ce461ab-97fb-40a4-bc3e-bdf9d12e9aa0EnglishSymplectic Elements at Oxford2010Julg, BWilliams, KReddy, SBishop, KQi, YCarrington, MGoulder, PNdung'u, TWalker, BEffective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13) or narrow ( |
| spellingShingle | Julg, B Williams, K Reddy, S Bishop, K Qi, Y Carrington, M Goulder, P Ndung'u, T Walker, B Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses. |
| title | Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses. |
| title_full | Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses. |
| title_fullStr | Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses. |
| title_full_unstemmed | Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses. |
| title_short | Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses. |
| title_sort | enhanced anti hiv functional activity associated with gag specific cd8 t cell responses |
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