Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.

Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses.

Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Julg, B, Williams, K, Reddy, S, Bishop, K, Qi, Y, Carrington, M, Goulder, P, Ndung'u, T, Walker, B
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2010

Παρόμοια τεκμήρια

Polyvalent Gag-specific CD8 T-cells with enhanced functional properties are enriched in HIV-1 clade C infected individuals with lower viral loads
ανά: Julg, B, κ.ά.
Έκδοση: (2009)

S04-06 OA. Polyvalent Gag-specific CD8 T-cells with enhanced functional properties are enriched in HIV-1 clade C infected individuals with lower viral loads
ανά: Julg, B, κ.ά.
Έκδοση: (2009)

Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells.
ανά: Ndhlovu, Z, κ.ά.
Έκδοση: (2011)

HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation.
ανά: Honeyborne, I, κ.ά.
Έκδοση: (2010)

Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
ανά: Wright, J, κ.ά.
Έκδοση: (2009)

HLA-B*4201-restricted inter- and intra-protein-specific differences in anti-HIV CD8(+) T-cell epitope efficacy
ανά: Kloverpris, H, κ.ά.
Έκδοση: (2010)

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
ανά: Wright, J, κ.ά.
Έκδοση: (2009)

Non-progressive paediatric HIV infection is associated with virus attenuation and increase in CD8+specific T cell responses over time
ανά: Prado, J, κ.ά.
Έκδοση: (2009)

P07-07. Non-progressive paediatric HIV infection is associated with virus attenuation and increase in CD8+ specific T cell responses over time
ανά: Prado, J, κ.ά.
Έκδοση: (2009)

P09-09. Impact of immune-driven sequence variation in HIV-1 subtype C Gag-Protease on viral fitness and disease progression
ανά: Goulder PJ, κ.ά.
Έκδοση: (2009-10-01)

Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
ανά: Mkhwanazi, N, κ.ά.
Έκδοση: (2010)

Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infected individuals.
ανά: Wright, J, κ.ά.
Έκδοση: (2012)

P07-07. Non-progressive paediatric HIV infection is associated with virus attenuation and increase in CD8+ specific T cell responses over time
ανά: Walker BD, κ.ά.
Έκδοση: (2009-10-01)

HLA-A*68:02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective.
ανά: Kløverpris, H, κ.ά.
Έκδοση: (2013)

HLA-A*68: 02-restricted Gag-specific cytotoxic T lymphocyte responses can drive selection pressure on HIV but are subdominant and ineffective
ανά: Kløverpris, H, κ.ά.
Έκδοση: (2013)

Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
ανά: Julg, B, κ.ά.
Έκδοση: (2011)

Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.
ανά: Ramduth, D, κ.ά.
Έκδοση: (2008)

Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity.
ανά: Wright, J, κ.ά.
Έκδοση: (2012)

Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa
ανά: Farinre, Omotayo, κ.ά.
Έκδοση: (2021)

Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa
ανά: Omotayo Farinre, κ.ά.
Έκδοση: (2021-05-01)

Gag-specific CD4+ T-cell responses are associated with virological control of paediatric HIV-1 infection.
ανά: Prendergast, A, κ.ά.
Έκδοση: (2011)

Gag-specific CD4+ T-cell responses are associated with virological control of paediatric HIV-1 infection
ανά: Prendergast, A, κ.ά.
Έκδοση: (2011)

Limited Sequence Variation and Similar Phenotypic Characteristics of HIV-1 Subtype C Gag Variants Derived From the Reservoir and Pre-Therapy Plasma
ανά: Doty Ojwach, κ.ά.
Έκδοση: (2022-07-01)

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
ανά: Wright, J, κ.ά.
Έκδοση: (2010)

Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells.
ανά: Payne, R, κ.ά.
Έκδοση: (2010)

HIV specific CD8+ TRM-like cells in tonsils express exhaustive signatures in the absence of natural HIV control
ανά: Rabiah Fardoos, κ.ά.
Έκδοση: (2022-10-01)

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
ανά: Honeyborne, I, κ.ά.
Έκδοση: (2007)

The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing
ανά: Mann, Jaclyn K., κ.ά.
Έκδοση: (2014)

Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
ανά: Thobakgale, C, κ.ά.
Έκδοση: (2011)

The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.
ανά: Jaclyn K Mann, κ.ά.
Έκδοση: (2014-08-01)

Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection.
ανά: Riou, C, κ.ά.
Έκδοση: (2012)

Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
ανά: Yu, X, κ.ά.
Έκδοση: (2002)

Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.
ανά: Rolland, M, κ.ά.
Έκδοση: (2008)

Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells.
ανά: Kløverpris, H, κ.ά.
Έκδοση: (2013)

Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape
ανά: Leitman, E, κ.ά.
Έκδοση: (2017)

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.
ανά: Leitman, E, κ.ά.
Έκδοση: (2017)

Early presentation of HIV-1 KF11Gag and KK10Gag protective epitopes facilitate rapid CD8+T cell activation and killing of virus infected cells
ανά: Kloverpris, H, κ.ά.
Έκδοση: (2012)

Combined Clinical and Immunological Biomarkers Predict Rates of CD4 Decline in Chronic Untreated HIV Infection
ανά: Brumme, Z, κ.ά.
Έκδοση: (2008)

Co-infection with Mycobacterium tuberculosis impairs HIV-Specific CD8+ and CD4+ T cell functionality.
ανά: Shivan Chetty, κ.ά.
Έκδοση: (2015-01-01)

Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
ανά: Rolland, M, κ.ά.
Έκδοση: (2010)