Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs.

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs.

Polycomb repressor complexes (PRCs) are important chromatin modifiers fundamentally implicated in pluripotency and cancer. Polycomb silencing in embryonic stem cells (ESCs) can be accompanied by active chromatin and primed RNA polymerase II (RNAPII), but the relationship between PRCs and RNAPII rema...

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Bibliographic Details
Main Authors: Brookes, E, de Santiago, I, Hebenstreit, D, Morris, K, Carroll, T, Xie, S, Stock, J, Heidemann, M, Eick, D, Nozaki, N, Kimura, H, Ragoussis, J, Teichmann, SA, Pombo, A
Format: Journal article
Language:English
Published: 2012

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