Human histone demethylase KDM6B can catalyse sequential oxidations
Jumonji domain-containing demethylases (JmjC-KDMs) catalyse demethylation of Nε-methylated lysines on histones and play important roles in gene regulation. We report selectivity studies on KDM6B (JMJD3), a disease-relevant JmjC-KDM, using synthetic lysine analogues. The results unexpectedly reveal t...
সম্পূর্ণ বিবরণ
গ্রন্থ-পঞ্জীর বিবরন
| প্রধান লেখক: |
Hopkinson, R,
Langley, G,
Belle, R,
Walport, L,
Dunne, K,
Münzel, M,
Salah, E,
Kawamura, A,
Claridge, T,
Schofield, C |
|---|
| বিন্যাস: | Journal article
|
|---|
| ভাষা: | English |
|---|
| প্রকাশিত: |
Royal Society of Chemistry
2018
|
|---|