Serotonin, dieting, and bulimia nervosa.
Dieting is a common behaviour which may trigger eating disorders such as bulimia nervosa in predisposed subjects. We found that in healthy women moderate dieting for 3 weeks lowered plasma concentrations of the 5-HT precursor, L-tryptophan (TRP) and impaired brain 5-HT neurotransmission as judged by...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797084804995350528 |
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| author | Cowen, P Smith, K |
| author_facet | Cowen, P Smith, K |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | Dieting is a common behaviour which may trigger eating disorders such as bulimia nervosa in predisposed subjects. We found that in healthy women moderate dieting for 3 weeks lowered plasma concentrations of the 5-HT precursor, L-tryptophan (TRP) and impaired brain 5-HT neurotransmission as judged by 5-HT neuroendocrine tests. In recovered female subjects with a history of bulimia nervosa we found that TRP depletion produced by an amino acid mixture lacking TRP caused a temporary return of depressive symptoms together with concerns about weight and shape and fear of loss of control of eating. Taken together the data suggest that dieting-induced decreases in TRP availability may trigger the development of bulimia nervosa is susceptible individuals. |
| first_indexed | 2024-03-07T02:00:12Z |
| format | Journal article |
| id | oxford-uuid:9d1b8f10-4a08-4cc6-ac46-474be7f46bec |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:00:12Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:9d1b8f10-4a08-4cc6-ac46-474be7f46bec2022-03-27T00:40:36ZSerotonin, dieting, and bulimia nervosa.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d1b8f10-4a08-4cc6-ac46-474be7f46becEnglishSymplectic Elements at Oxford1999Cowen, PSmith, KDieting is a common behaviour which may trigger eating disorders such as bulimia nervosa in predisposed subjects. We found that in healthy women moderate dieting for 3 weeks lowered plasma concentrations of the 5-HT precursor, L-tryptophan (TRP) and impaired brain 5-HT neurotransmission as judged by 5-HT neuroendocrine tests. In recovered female subjects with a history of bulimia nervosa we found that TRP depletion produced by an amino acid mixture lacking TRP caused a temporary return of depressive symptoms together with concerns about weight and shape and fear of loss of control of eating. Taken together the data suggest that dieting-induced decreases in TRP availability may trigger the development of bulimia nervosa is susceptible individuals. |
| spellingShingle | Cowen, P Smith, K Serotonin, dieting, and bulimia nervosa. |
| title | Serotonin, dieting, and bulimia nervosa. |
| title_full | Serotonin, dieting, and bulimia nervosa. |
| title_fullStr | Serotonin, dieting, and bulimia nervosa. |
| title_full_unstemmed | Serotonin, dieting, and bulimia nervosa. |
| title_short | Serotonin, dieting, and bulimia nervosa. |
| title_sort | serotonin dieting and bulimia nervosa |
| work_keys_str_mv | AT cowenp serotonindietingandbulimianervosa AT smithk serotonindietingandbulimianervosa |