Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers.
Neisseria gonorrhoeae cervicitis and human immunodeficiency virus (HIV) type 1 frequently coinfect core transmitter populations, such as female sex workers. Gonococcal cervicitis is associated with increased viral shedding and plasma viremia in HIV-1-infected women and increased HIV-1 susceptibility...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1826287544261672960 |
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| author | Kaul, R Rowland-Jones, S Gillespie, G Kimani, J Dong, T Kiama, P Simonsen, J Bwayo, J Mcmichael, A Plummer, F |
| author_facet | Kaul, R Rowland-Jones, S Gillespie, G Kimani, J Dong, T Kiama, P Simonsen, J Bwayo, J Mcmichael, A Plummer, F |
| author_sort | Kaul, R |
| collection | OXFORD |
| description | Neisseria gonorrhoeae cervicitis and human immunodeficiency virus (HIV) type 1 frequently coinfect core transmitter populations, such as female sex workers. Gonococcal cervicitis is associated with increased viral shedding and plasma viremia in HIV-1-infected women and increased HIV-1 susceptibility in uninfected women. We studied the influence of gonococcal cervicitis on CD8(+) interferon (IFN)-gamma responses to HIV-1 and cytomegalovirus (CMV) epitopes in HIV-1-infected and in highly-exposed, persistently seronegative (HEPS) female sex workers. In HIV-1-infected women, gonococcal cervicitis was associated with reduced IFN-gamma responses in bulk CD8(+) lymphocyte populations, and intracellular cytokine staining, combined with class I major histocompatibility complex (MHC)-peptide tetramer studies, demonstrated reduced IFN-gamma production by HIV-1 epitope-specific CD8(+) lymphocytes. In HEPS sex workers, cervicitis was associated with the transient loss of systemic HIV-1-specific CD8(+) responses and with reduced function of CMV-specific CD8(+) lymphocytes. Impaired function of virus-specific CD8(+) lymphocytes may partly explain the deleterious effects of gonococcal cervicitis on HIV-1 immune control and susceptibility. |
| first_indexed | 2024-03-07T02:00:16Z |
| format | Journal article |
| id | oxford-uuid:9d20d166-36c3-4fbe-9a48-ebb0879b0da5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:00:16Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:9d20d166-36c3-4fbe-9a48-ebb0879b0da52022-03-27T00:40:50ZGonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d20d166-36c3-4fbe-9a48-ebb0879b0da5EnglishSymplectic Elements at Oxford2002Kaul, RRowland-Jones, SGillespie, GKimani, JDong, TKiama, PSimonsen, JBwayo, JMcmichael, APlummer, FNeisseria gonorrhoeae cervicitis and human immunodeficiency virus (HIV) type 1 frequently coinfect core transmitter populations, such as female sex workers. Gonococcal cervicitis is associated with increased viral shedding and plasma viremia in HIV-1-infected women and increased HIV-1 susceptibility in uninfected women. We studied the influence of gonococcal cervicitis on CD8(+) interferon (IFN)-gamma responses to HIV-1 and cytomegalovirus (CMV) epitopes in HIV-1-infected and in highly-exposed, persistently seronegative (HEPS) female sex workers. In HIV-1-infected women, gonococcal cervicitis was associated with reduced IFN-gamma responses in bulk CD8(+) lymphocyte populations, and intracellular cytokine staining, combined with class I major histocompatibility complex (MHC)-peptide tetramer studies, demonstrated reduced IFN-gamma production by HIV-1 epitope-specific CD8(+) lymphocytes. In HEPS sex workers, cervicitis was associated with the transient loss of systemic HIV-1-specific CD8(+) responses and with reduced function of CMV-specific CD8(+) lymphocytes. Impaired function of virus-specific CD8(+) lymphocytes may partly explain the deleterious effects of gonococcal cervicitis on HIV-1 immune control and susceptibility. |
| spellingShingle | Kaul, R Rowland-Jones, S Gillespie, G Kimani, J Dong, T Kiama, P Simonsen, J Bwayo, J Mcmichael, A Plummer, F Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers. |
| title | Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers. |
| title_full | Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers. |
| title_fullStr | Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers. |
| title_full_unstemmed | Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers. |
| title_short | Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers. |
| title_sort | gonococcal cervicitis is associated with reduced systemic cd8 t cell responses in human immunodeficiency virus type 1 infected and exposed uninfected sex workers |
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