Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis
<p><strong>Background</p></strong> Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB). <p><strong> Objectives</p></strong> This study aimed to...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2023
|
| _version_ | 1826315149929086976 |
|---|---|
| author | Monangi, NK Xu, H Fan, Y-M Khanam, R Khan, W Deb, S Pervin, J Price, JT Kaur, L Villar, J McGready, R Barros, FC Victora, CG Munim, S Papageorghiou, A Ochieng, R Craik, R Barososio, HC Berkley, JA Carvalho, M Ismail, LC Lambert, A Norris, SA Tshivuila-Matela, C Nosten, F Uauy, R Bhutta, Z Kennedy, S |
| author2 | INTERBIO-21st Study Consortium |
| author_facet | INTERBIO-21st Study Consortium Monangi, NK Xu, H Fan, Y-M Khanam, R Khan, W Deb, S Pervin, J Price, JT Kaur, L Villar, J McGready, R Barros, FC Victora, CG Munim, S Papageorghiou, A Ochieng, R Craik, R Barososio, HC Berkley, JA Carvalho, M Ismail, LC Lambert, A Norris, SA Tshivuila-Matela, C Nosten, F Uauy, R Bhutta, Z Kennedy, S |
| author_sort | Monangi, NK |
| collection | OXFORD |
| description | <p><strong>Background</p></strong>
Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).
<p><strong>
Objectives</p></strong>
This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.
<p><strong>
Methods</p></strong>
Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort.
<p><strong>
Results</p></strong>
The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration.
<p><strong>
Conclusions</p></strong>
Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB. |
| first_indexed | 2024-12-09T03:21:18Z |
| format | Journal article |
| id | oxford-uuid:9d25db37-1760-4bae-a03d-dd400a0855cd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:21:18Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:9d25db37-1760-4bae-a03d-dd400a0855cd2024-11-12T14:24:22ZAssociation of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d25db37-1760-4bae-a03d-dd400a0855cdEnglishSymplectic ElementsElsevier2023Monangi, NKXu, HFan, Y-MKhanam, RKhan, WDeb, SPervin, JPrice, JTKaur, LVillar, JMcGready, RBarros, FCVictora, CGMunim, SPapageorghiou, AOchieng, RCraik, RBarososio, HCBerkley, JACarvalho, MIsmail, LCLambert, ANorris, SATshivuila-Matela, CNosten, FUauy, RBhutta, ZKennedy, SINTERBIO-21st Study Consortium<p><strong>Background</p></strong> Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB). <p><strong> Objectives</p></strong> This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations. <p><strong> Methods</p></strong> Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort. <p><strong> Results</p></strong> The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration. <p><strong> Conclusions</p></strong> Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB. |
| spellingShingle | Monangi, NK Xu, H Fan, Y-M Khanam, R Khan, W Deb, S Pervin, J Price, JT Kaur, L Villar, J McGready, R Barros, FC Victora, CG Munim, S Papageorghiou, A Ochieng, R Craik, R Barososio, HC Berkley, JA Carvalho, M Ismail, LC Lambert, A Norris, SA Tshivuila-Matela, C Nosten, F Uauy, R Bhutta, Z Kennedy, S Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis |
| title | Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis |
| title_full | Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis |
| title_fullStr | Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis |
| title_full_unstemmed | Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis |
| title_short | Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis |
| title_sort | association of maternal prenatal copper concentration with gestational duration and preterm birth a multicountry meta analysis |
| work_keys_str_mv | AT monangink associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT xuh associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT fanym associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT khanamr associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT khanw associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT debs associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT pervinj associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT pricejt associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT kaurl associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT villarj associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT mcgreadyr associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT barrosfc associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT victoracg associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT munims associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT papageorghioua associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT ochiengr associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT craikr associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT barososiohc associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT berkleyja associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT carvalhom associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT ismaillc associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT lamberta associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT norrissa associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT tshivuilamatelac associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT nostenf associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT uauyr associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT bhuttaz associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis AT kennedys associationofmaternalprenatalcopperconcentrationwithgestationaldurationandpretermbirthamulticountrymetaanalysis |