Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study.
74 insulin-dependent diabetic patients with background retinopathy were randomised to continue with usual diabetic care (group U) or to a more intensive programme (group A) using ultralente insulin as basal cover and soluble insulin at mealtimes. Group A attended the clinic more frequently, received...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1983
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| _version_ | 1797084828763422720 |
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| author | Holman, R Dornan, T Mayon-White, V Howard-Williams, J Orde-Peckar, C Jenkins, L Steemson, J Rolfe, R Smith, B Barbour, D McPherson, K Poon, P Rizza, C Mann, J Knight, A Bron, A Turner, R |
| author_facet | Holman, R Dornan, T Mayon-White, V Howard-Williams, J Orde-Peckar, C Jenkins, L Steemson, J Rolfe, R Smith, B Barbour, D McPherson, K Poon, P Rizza, C Mann, J Knight, A Bron, A Turner, R |
| author_sort | Holman, R |
| collection | OXFORD |
| description | 74 insulin-dependent diabetic patients with background retinopathy were randomised to continue with usual diabetic care (group U) or to a more intensive programme (group A) using ultralente insulin as basal cover and soluble insulin at mealtimes. Group A attended the clinic more frequently, received closer dietary supervision, and were taught home blood glucose monitoring. Group A had a significantly lower mean glycosylated haemoglobin level during the study, although the mean level also fell in group U towards the end of year 2. Renal and sensory-nerve function were significantly better preserved in group A than in group U. Significant improvements were also seen in low-density-lipoprotein-cholesterol and whole-blood low-shear viscosity. The rate of progression of retinopathy was similar in both groups. It appears that a modest improvement in diabetic control, obtainable in most clinics, has been associated with a reduction in the progression of diabetic tissue damage. |
| first_indexed | 2024-03-07T02:00:33Z |
| format | Journal article |
| id | oxford-uuid:9d39b406-bf27-49ad-b4c3-ce084c3791a3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:00:33Z |
| publishDate | 1983 |
| record_format | dspace |
| spelling | oxford-uuid:9d39b406-bf27-49ad-b4c3-ce084c3791a32022-03-27T00:41:24ZPrevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d39b406-bf27-49ad-b4c3-ce084c3791a3EnglishSymplectic Elements at Oxford1983Holman, RDornan, TMayon-White, VHoward-Williams, JOrde-Peckar, CJenkins, LSteemson, JRolfe, RSmith, BBarbour, DMcPherson, KPoon, PRizza, CMann, JKnight, ABron, ATurner, R74 insulin-dependent diabetic patients with background retinopathy were randomised to continue with usual diabetic care (group U) or to a more intensive programme (group A) using ultralente insulin as basal cover and soluble insulin at mealtimes. Group A attended the clinic more frequently, received closer dietary supervision, and were taught home blood glucose monitoring. Group A had a significantly lower mean glycosylated haemoglobin level during the study, although the mean level also fell in group U towards the end of year 2. Renal and sensory-nerve function were significantly better preserved in group A than in group U. Significant improvements were also seen in low-density-lipoprotein-cholesterol and whole-blood low-shear viscosity. The rate of progression of retinopathy was similar in both groups. It appears that a modest improvement in diabetic control, obtainable in most clinics, has been associated with a reduction in the progression of diabetic tissue damage. |
| spellingShingle | Holman, R Dornan, T Mayon-White, V Howard-Williams, J Orde-Peckar, C Jenkins, L Steemson, J Rolfe, R Smith, B Barbour, D McPherson, K Poon, P Rizza, C Mann, J Knight, A Bron, A Turner, R Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study. |
| title | Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study. |
| title_full | Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study. |
| title_fullStr | Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study. |
| title_full_unstemmed | Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study. |
| title_short | Prevention of deterioration of renal and sensory-nerve function by more intensive management of insulin-dependent diabetic patients. A two-year randomised prospective study. |
| title_sort | prevention of deterioration of renal and sensory nerve function by more intensive management of insulin dependent diabetic patients a two year randomised prospective study |
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