Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.
The chromosome 21q22.11 cytokine receptor cluster contains four genes that encode subunits of the receptors for the cytokines interleukin-10 and interferon-alpha, -beta and -gamma that may have a role in malaria pathogenesis. A total of 15 polymorphic markers located within these genes were initiall...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1826287569680203776 |
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| author | Aucan, C Walley, A Hennig, B Fitness, J Frodsham, A Zhang, L Kwiatkowski, D Hill, A |
| author_facet | Aucan, C Walley, A Hennig, B Fitness, J Frodsham, A Zhang, L Kwiatkowski, D Hill, A |
| author_sort | Aucan, C |
| collection | OXFORD |
| description | The chromosome 21q22.11 cytokine receptor cluster contains four genes that encode subunits of the receptors for the cytokines interleukin-10 and interferon-alpha, -beta and -gamma that may have a role in malaria pathogenesis. A total of 15 polymorphic markers located within these genes were initially genotyped in 190 controls and 190 severe malaria cases from The Gambia. Two interferon-alpha receptor-1 (IFNAR1) gene SNPs (17470 and L168 V) showed evidence for an association with severe malaria phenotypes and were typed in a larger series of samples comprising 538 severe malaria cases, 338 mild malaria cases and 562 controls. Both the 17470-G/G and L168V-G/G genotypes were associated with protection against severe malaria, in general, and cerebral malaria, in particular (P=0.004 and 0.003, respectively). IFNAR1 diplotypes were then constructed for these two markers using the PHASE software package. The (17470-G L168V-G/17470-G L168V-G) diplotype was found to be associated with a reduced risk of cerebral malaria and the (17470-C L168V-C/17470-G L168V-G) diplotype with an increased risk of cerebral malaria (overall 3 x 2 chi(2)=12.8, d.f.=2, P=0.002 and 3 x 2 chi(2)=15.2, d.f.=2, P=0.0005, respectively). These data suggest a role for the type I interferon pathway in resistance to cerebral malaria. |
| first_indexed | 2024-03-07T02:00:37Z |
| format | Journal article |
| id | oxford-uuid:9d3e5ab3-d01f-42f7-94e2-f192fdaa4393 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:00:37Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:9d3e5ab3-d01f-42f7-94e2-f192fdaa43932022-03-27T00:41:31ZInterferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d3e5ab3-d01f-42f7-94e2-f192fdaa4393EnglishSymplectic Elements at Oxford2003Aucan, CWalley, AHennig, BFitness, JFrodsham, AZhang, LKwiatkowski, DHill, AThe chromosome 21q22.11 cytokine receptor cluster contains four genes that encode subunits of the receptors for the cytokines interleukin-10 and interferon-alpha, -beta and -gamma that may have a role in malaria pathogenesis. A total of 15 polymorphic markers located within these genes were initially genotyped in 190 controls and 190 severe malaria cases from The Gambia. Two interferon-alpha receptor-1 (IFNAR1) gene SNPs (17470 and L168 V) showed evidence for an association with severe malaria phenotypes and were typed in a larger series of samples comprising 538 severe malaria cases, 338 mild malaria cases and 562 controls. Both the 17470-G/G and L168V-G/G genotypes were associated with protection against severe malaria, in general, and cerebral malaria, in particular (P=0.004 and 0.003, respectively). IFNAR1 diplotypes were then constructed for these two markers using the PHASE software package. The (17470-G L168V-G/17470-G L168V-G) diplotype was found to be associated with a reduced risk of cerebral malaria and the (17470-C L168V-C/17470-G L168V-G) diplotype with an increased risk of cerebral malaria (overall 3 x 2 chi(2)=12.8, d.f.=2, P=0.002 and 3 x 2 chi(2)=15.2, d.f.=2, P=0.0005, respectively). These data suggest a role for the type I interferon pathway in resistance to cerebral malaria. |
| spellingShingle | Aucan, C Walley, A Hennig, B Fitness, J Frodsham, A Zhang, L Kwiatkowski, D Hill, A Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. |
| title | Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. |
| title_full | Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. |
| title_fullStr | Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. |
| title_full_unstemmed | Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. |
| title_short | Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in the Gambia. |
| title_sort | interferon alpha receptor 1 ifnar1 variants are associated with protection against cerebral malaria in the gambia |
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