Ectopic Cushing's syndrome secondary to olfactory neuroblastoma

Ectopic Cushing's syndrome secondary to olfactory neuroblastoma

We present the case of a patient with Cushing's syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination s...

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Bibliographic Details
Main Authors: Yu, K, Roncaroli, F, Kearney, T, Ewins, D, Beeharry, D, Naylor, T, Ray, D, Bhalla, R, Gnanalingham, K
Format: Journal article
Language:English
Published: Springer Nature 2018
Description
Summary:We present the case of a patient with Cushing's syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient's cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.

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