Does MSI-low exist?
Microsatellite instability is a well-recognised phenomenon. Ten to 15% of sporadic colorectal cancers with a high level of MSI form a well defined group with distinct clinicopathological features. The set of tumours with low level of microsatellite instability (MSI-low), though widely referred to, i...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1797084878736457728 |
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| author | Tomlinson, I Halford, S Aaltonen, L Hawkins, N Ward, R |
| author_facet | Tomlinson, I Halford, S Aaltonen, L Hawkins, N Ward, R |
| author_sort | Tomlinson, I |
| collection | OXFORD |
| description | Microsatellite instability is a well-recognised phenomenon. Ten to 15% of sporadic colorectal cancers with a high level of MSI form a well defined group with distinct clinicopathological features. The set of tumours with low level of microsatellite instability (MSI-low), though widely referred to, is not a clearly defined group. The definitions of MSI-low have varied among groups and between different studies from the same group. Some studies have found associations between the MSI-L phenotype and molecular features, notably a higher frequency of K-ras mutations, and, possibly, methylation of methylguanine methyltransferase. Two recent independent studies, however, showed respectively that 68% and 79%, non-MSI-H cancers showed some MSI and could therefore be classed nominally as MSI-L. There was no evidence for a qualitatively discrete MSI-L group, but quantitative differences in the level of MSI were found. |
| first_indexed | 2024-03-07T02:01:19Z |
| format | Journal article |
| id | oxford-uuid:9d75de6c-99ce-41cd-b964-a7f66eac9436 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:01:19Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:9d75de6c-99ce-41cd-b964-a7f66eac94362022-03-27T00:43:14ZDoes MSI-low exist?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d75de6c-99ce-41cd-b964-a7f66eac9436EnglishSymplectic Elements at Oxford2002Tomlinson, IHalford, SAaltonen, LHawkins, NWard, RMicrosatellite instability is a well-recognised phenomenon. Ten to 15% of sporadic colorectal cancers with a high level of MSI form a well defined group with distinct clinicopathological features. The set of tumours with low level of microsatellite instability (MSI-low), though widely referred to, is not a clearly defined group. The definitions of MSI-low have varied among groups and between different studies from the same group. Some studies have found associations between the MSI-L phenotype and molecular features, notably a higher frequency of K-ras mutations, and, possibly, methylation of methylguanine methyltransferase. Two recent independent studies, however, showed respectively that 68% and 79%, non-MSI-H cancers showed some MSI and could therefore be classed nominally as MSI-L. There was no evidence for a qualitatively discrete MSI-L group, but quantitative differences in the level of MSI were found. |
| spellingShingle | Tomlinson, I Halford, S Aaltonen, L Hawkins, N Ward, R Does MSI-low exist? |
| title | Does MSI-low exist? |
| title_full | Does MSI-low exist? |
| title_fullStr | Does MSI-low exist? |
| title_full_unstemmed | Does MSI-low exist? |
| title_short | Does MSI-low exist? |
| title_sort | does msi low exist |
| work_keys_str_mv | AT tomlinsoni doesmsilowexist AT halfords doesmsilowexist AT aaltonenl doesmsilowexist AT hawkinsn doesmsilowexist AT wardr doesmsilowexist |