An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation
Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C–C bond forming step.
| 主要な著者: | , |
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| フォーマット: | Journal article |
| 出版事項: |
Royal Society of Chemistry
2015
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| 主題: |
| _version_ | 1826287621095030784 |
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| author | Caprioglio, D Fletcher, S |
| author_facet | Caprioglio, D Fletcher, S |
| author_sort | Caprioglio, D |
| collection | OXFORD |
| description | Fulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C–C bond forming step. |
| first_indexed | 2024-03-07T02:01:24Z |
| format | Journal article |
| id | oxford-uuid:9d7d6d0d-695f-4494-9ac6-2bcbf18d0900 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:01:24Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:9d7d6d0d-695f-4494-9ac6-2bcbf18d09002022-03-27T00:43:28ZAn alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d7d6d0d-695f-4494-9ac6-2bcbf18d0900ChemistryORA DepositRoyal Society of Chemistry2015Caprioglio, DFletcher, SFulvestrant (Faslodex®) was synthesized in four steps (35% overall yield) from 6-dehydronandrolone acetate. Catalyst controlled, room temperature, diastereoselective 1,6-addition of the zirconocene derived from commercially available 9-bromonon-1-ene was used in the key C–C bond forming step. |
| spellingShingle | Chemistry Caprioglio, D Fletcher, S An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation |
| title | An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation |
| title_full | An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation |
| title_fullStr | An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation |
| title_full_unstemmed | An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation |
| title_short | An alternative synthesis of the breast cancer drug fulvestrant (Faslodexs): catalyst control over C–C bond formation |
| title_sort | alternative synthesis of the breast cancer drug fulvestrant faslodexs catalyst control over c c bond formation |
| topic | Chemistry |
| work_keys_str_mv | AT capriogliod analternativesynthesisofthebreastcancerdrugfulvestrantfaslodexscatalystcontroloverccbondformation AT fletchers analternativesynthesisofthebreastcancerdrugfulvestrantfaslodexscatalystcontroloverccbondformation AT capriogliod alternativesynthesisofthebreastcancerdrugfulvestrantfaslodexscatalystcontroloverccbondformation AT fletchers alternativesynthesisofthebreastcancerdrugfulvestrantfaslodexscatalystcontroloverccbondformation |