Mitochondrial content is central to nuclear gene expression: profound implications for human health
<p>We review a recent paper in Genome Research by Guantes et al. showing that nuclear gene expression is influenced by the bioenergetic status of the mitochondria.</p> <p>The amount of energy that mitochondria make available for gene expression varies considerably. It depends on: t...
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| Format: | Journal article |
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Wiley
2016
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| _version_ | 1797084892216950784 |
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| author | Muir, R Diot, A Poulton, J |
| author_facet | Muir, R Diot, A Poulton, J |
| author_sort | Muir, R |
| collection | OXFORD |
| description | <p>We review a recent paper in Genome Research by Guantes et al. showing that nuclear gene expression is influenced by the bioenergetic status of the mitochondria.</p> <p>The amount of energy that mitochondria make available for gene expression varies considerably. It depends on: the energetic demands of the tissue; the mitochondrial DNA (mtDNA) mutant load; the number of mitochondria; stressors present in the cell. Hence, when failing mitochondria place the cell in energy crisis there are major effects on gene expression affecting the risk of degenerative diseases, cancer and ageing.</p> <p>In 2015 the UK parliament approved a change in the regulation of IVF techniques, allowing ‘Mitochondrial replacement therapy’ to become a reproductive choice for women at risk of transmitting mitochondrial disease to their children. This is the first time that this technique will be available. Therefore understanding the interaction between mitochondria and the nucleus has never been more important.</p> |
| first_indexed | 2024-03-07T02:01:31Z |
| format | Journal article |
| id | oxford-uuid:9d843823-6a73-4d51-bd5c-e5ea1de8d130 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:01:31Z |
| publishDate | 2016 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:9d843823-6a73-4d51-bd5c-e5ea1de8d1302022-03-27T00:43:42ZMitochondrial content is central to nuclear gene expression: profound implications for human healthJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d843823-6a73-4d51-bd5c-e5ea1de8d130Symplectic Elements at OxfordWiley2016Muir, RDiot, APoulton, J<p>We review a recent paper in Genome Research by Guantes et al. showing that nuclear gene expression is influenced by the bioenergetic status of the mitochondria.</p> <p>The amount of energy that mitochondria make available for gene expression varies considerably. It depends on: the energetic demands of the tissue; the mitochondrial DNA (mtDNA) mutant load; the number of mitochondria; stressors present in the cell. Hence, when failing mitochondria place the cell in energy crisis there are major effects on gene expression affecting the risk of degenerative diseases, cancer and ageing.</p> <p>In 2015 the UK parliament approved a change in the regulation of IVF techniques, allowing ‘Mitochondrial replacement therapy’ to become a reproductive choice for women at risk of transmitting mitochondrial disease to their children. This is the first time that this technique will be available. Therefore understanding the interaction between mitochondria and the nucleus has never been more important.</p> |
| spellingShingle | Muir, R Diot, A Poulton, J Mitochondrial content is central to nuclear gene expression: profound implications for human health |
| title | Mitochondrial content is central to nuclear gene expression: profound implications for human health |
| title_full | Mitochondrial content is central to nuclear gene expression: profound implications for human health |
| title_fullStr | Mitochondrial content is central to nuclear gene expression: profound implications for human health |
| title_full_unstemmed | Mitochondrial content is central to nuclear gene expression: profound implications for human health |
| title_short | Mitochondrial content is central to nuclear gene expression: profound implications for human health |
| title_sort | mitochondrial content is central to nuclear gene expression profound implications for human health |
| work_keys_str_mv | AT muirr mitochondrialcontentiscentraltonucleargeneexpressionprofoundimplicationsforhumanhealth AT diota mitochondrialcontentiscentraltonucleargeneexpressionprofoundimplicationsforhumanhealth AT poultonj mitochondrialcontentiscentraltonucleargeneexpressionprofoundimplicationsforhumanhealth |