Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
BACKGROUND: The HLA class II molecules play a central role in the generation of human immunodeficiency virus (HIV)-specific CD4(+) T-helper cells, which are critical for the induction of cytotoxic CD8(+) T cell responses. However, little is known about the impact of HLA class II alleles on HIV disea...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826287628722372608 |
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| author | Julg, B Moodley, E Qi, Y Ramduth, D Reddy, S Mncube, Z Gao, X Goulder, P Detels, R Ndung'u, T Walker, B Carrington, M |
| author_facet | Julg, B Moodley, E Qi, Y Ramduth, D Reddy, S Mncube, Z Gao, X Goulder, P Detels, R Ndung'u, T Walker, B Carrington, M |
| author_sort | Julg, B |
| collection | OXFORD |
| description | BACKGROUND: The HLA class II molecules play a central role in the generation of human immunodeficiency virus (HIV)-specific CD4(+) T-helper cells, which are critical for the induction of cytotoxic CD8(+) T cell responses. However, little is known about the impact of HLA class II alleles on HIV disease progression. METHODS: In this study we investigated the effect of HLA class II alleles on HIV disease outcome and HIV-specific T cell responses in a cohort of 426 antiretroviral therapy-naive, HIV-1 clade C-infected, predominantly female black South Africans. RESULTS: The HLA class II allele DRB1*1303 was independently associated with lower plasma viral loads in this population (P = .02), an association that was confirmed in a second cohort of 1436 untreated, HIV-1 clade B-infected, male European Americans, suggesting that DRB1*1303-mediated protection is independent of ethnicity, sex, and viral clade. Interestingly, DRB1*1303 carriage was not associated with an increased frequency of interferon (IFN) γ-positive HIV-specific CD4(+) T cell responses. CONCLUSIONS: These data demonstrate the independent effect of an HLA class II allele, DRB1*1303, on HIV disease progression, in the absence of increased IFN-γ-positive HIV-specific CD4(+) T cell frequencies, suggesting that the protective activity of DRB1*1303 may be mediated via an alternative mechanism. |
| first_indexed | 2024-03-07T02:01:31Z |
| format | Journal article |
| id | oxford-uuid:9d84a1c3-205c-44c6-ab97-99e4501cf7a9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:01:31Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:9d84a1c3-205c-44c6-ab97-99e4501cf7a92022-03-27T00:43:41ZPossession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9d84a1c3-205c-44c6-ab97-99e4501cf7a9EnglishSymplectic Elements at Oxford2011Julg, BMoodley, EQi, YRamduth, DReddy, SMncube, ZGao, XGoulder, PDetels, RNdung'u, TWalker, BCarrington, MBACKGROUND: The HLA class II molecules play a central role in the generation of human immunodeficiency virus (HIV)-specific CD4(+) T-helper cells, which are critical for the induction of cytotoxic CD8(+) T cell responses. However, little is known about the impact of HLA class II alleles on HIV disease progression. METHODS: In this study we investigated the effect of HLA class II alleles on HIV disease outcome and HIV-specific T cell responses in a cohort of 426 antiretroviral therapy-naive, HIV-1 clade C-infected, predominantly female black South Africans. RESULTS: The HLA class II allele DRB1*1303 was independently associated with lower plasma viral loads in this population (P = .02), an association that was confirmed in a second cohort of 1436 untreated, HIV-1 clade B-infected, male European Americans, suggesting that DRB1*1303-mediated protection is independent of ethnicity, sex, and viral clade. Interestingly, DRB1*1303 carriage was not associated with an increased frequency of interferon (IFN) γ-positive HIV-specific CD4(+) T cell responses. CONCLUSIONS: These data demonstrate the independent effect of an HLA class II allele, DRB1*1303, on HIV disease progression, in the absence of increased IFN-γ-positive HIV-specific CD4(+) T cell frequencies, suggesting that the protective activity of DRB1*1303 may be mediated via an alternative mechanism. |
| spellingShingle | Julg, B Moodley, E Qi, Y Ramduth, D Reddy, S Mncube, Z Gao, X Goulder, P Detels, R Ndung'u, T Walker, B Carrington, M Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. |
| title | Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. |
| title_full | Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. |
| title_fullStr | Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. |
| title_full_unstemmed | Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. |
| title_short | Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. |
| title_sort | possession of hla class ii drb1 1303 associates with reduced viral loads in chronic hiv 1 clade c and b infection |
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