RNAi-mediated knockdown of HMG CoA reductase enhances gene expression from physiologically regulated low-density lipoprotein receptor therapeutic vectors in vivo.

The development of novel strategies to enhance gene expression from therapeutic vectors may prove advantageous for complementation gene therapy. This applies to therapeutic expression of the low-density lipoprotein receptor (LDLR) gene to treat familial hypercholesterolaemia (FH), where appropriate...

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書目詳細資料
Main Authors: Hibbitt, O, Agkatsev, S, Owen, C, Cioroch, M, Seymour, L, Channon, K, Wade-Martins, R
格式: Journal article
語言:English
出版: 2012