Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired functioning associated with the disorder and are not responsive to existing treatments. In this review, we first describe the clinical presentation and natural history of these deficits. We then consider aetiolo...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2023
|
| Subjects: |
| _version_ | 1797111092037550080 |
|---|---|
| author | McCutcheon, RA Keefe, RSE McGuire, PK |
| author_facet | McCutcheon, RA Keefe, RSE McGuire, PK |
| author_sort | McCutcheon, RA |
| collection | OXFORD |
| description | Cognitive deficits are a core feature of schizophrenia, account for much of the impaired functioning associated with the disorder and are not responsive to existing treatments. In this review, we first describe the clinical presentation and natural history of these deficits. We then consider aetiological factors, highlighting how a range of similar genetic and environmental factors are associated with both cognitive function and schizophrenia. We then review the pathophysiological mechanisms thought to underlie cognitive symptoms, including the role of dopamine, cholinergic signalling and the balance between GABAergic interneurons and glutamatergic pyramidal cells. Finally, we review the clinical management of cognitive impairments and candidate novel treatments. |
| first_indexed | 2024-03-07T08:03:54Z |
| format | Journal article |
| id | oxford-uuid:9dbcec4d-cbbf-4c6a-a3c2-2c123231212b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:03:54Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:9dbcec4d-cbbf-4c6a-a3c2-2c123231212b2023-10-18T11:30:12ZCognitive impairment in schizophrenia: aetiology, pathophysiology, and treatmentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9dbcec4d-cbbf-4c6a-a3c2-2c123231212bNeuroscienceSchizophreniaEnglishSymplectic ElementsSpringer Nature2023McCutcheon, RAKeefe, RSEMcGuire, PKCognitive deficits are a core feature of schizophrenia, account for much of the impaired functioning associated with the disorder and are not responsive to existing treatments. In this review, we first describe the clinical presentation and natural history of these deficits. We then consider aetiological factors, highlighting how a range of similar genetic and environmental factors are associated with both cognitive function and schizophrenia. We then review the pathophysiological mechanisms thought to underlie cognitive symptoms, including the role of dopamine, cholinergic signalling and the balance between GABAergic interneurons and glutamatergic pyramidal cells. Finally, we review the clinical management of cognitive impairments and candidate novel treatments. |
| spellingShingle | Neuroscience Schizophrenia McCutcheon, RA Keefe, RSE McGuire, PK Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment |
| title | Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment |
| title_full | Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment |
| title_fullStr | Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment |
| title_full_unstemmed | Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment |
| title_short | Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment |
| title_sort | cognitive impairment in schizophrenia aetiology pathophysiology and treatment |
| topic | Neuroscience Schizophrenia |
| work_keys_str_mv | AT mccutcheonra cognitiveimpairmentinschizophreniaaetiologypathophysiologyandtreatment AT keeferse cognitiveimpairmentinschizophreniaaetiologypathophysiologyandtreatment AT mcguirepk cognitiveimpairmentinschizophreniaaetiologypathophysiologyandtreatment |