Azathioprine hypersensitivity presenting as septic shock with encephalopathy.
We present a case of azathioprine hypersensitivity presenting as septic shock with associated encephalopathy. The patient was presented with rapid onset of fever, hypotension, confusion and a rapidly declining conscious level. He was admitted to the intensive care unit where he received numerous inv...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2013
|
| _version_ | 1826287706260373504 |
|---|---|
| author | James, A Blagojevic, J Benham, S Cornall, R Frater, J |
| author_facet | James, A Blagojevic, J Benham, S Cornall, R Frater, J |
| author_sort | James, A |
| collection | OXFORD |
| description | We present a case of azathioprine hypersensitivity presenting as septic shock with associated encephalopathy. The patient was presented with rapid onset of fever, hypotension, confusion and a rapidly declining conscious level. He was admitted to the intensive care unit where he received numerous invasive investigations and treatments with broad-spectrum antibiotics, antivirals and antifungals. All microbial cultures were negative. The patient-consistent with azathioprine hypersensitivity-made a spontaneous recovery after 7 days. The case shows that a time line of drug initiation is a key part of the medical history and consideration of azathioprine hypersensitivity could avoid unnecessary interventions and excessive antimicrobial use. |
| first_indexed | 2024-03-07T02:02:41Z |
| format | Journal article |
| id | oxford-uuid:9de5d6de-e367-46fc-a81f-44a8501c2348 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:02:41Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:9de5d6de-e367-46fc-a81f-44a8501c23482022-03-27T00:46:25ZAzathioprine hypersensitivity presenting as septic shock with encephalopathy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9de5d6de-e367-46fc-a81f-44a8501c2348EnglishSymplectic Elements at Oxford2013James, ABlagojevic, JBenham, SCornall, RFrater, JWe present a case of azathioprine hypersensitivity presenting as septic shock with associated encephalopathy. The patient was presented with rapid onset of fever, hypotension, confusion and a rapidly declining conscious level. He was admitted to the intensive care unit where he received numerous invasive investigations and treatments with broad-spectrum antibiotics, antivirals and antifungals. All microbial cultures were negative. The patient-consistent with azathioprine hypersensitivity-made a spontaneous recovery after 7 days. The case shows that a time line of drug initiation is a key part of the medical history and consideration of azathioprine hypersensitivity could avoid unnecessary interventions and excessive antimicrobial use. |
| spellingShingle | James, A Blagojevic, J Benham, S Cornall, R Frater, J Azathioprine hypersensitivity presenting as septic shock with encephalopathy. |
| title | Azathioprine hypersensitivity presenting as septic shock with encephalopathy. |
| title_full | Azathioprine hypersensitivity presenting as septic shock with encephalopathy. |
| title_fullStr | Azathioprine hypersensitivity presenting as septic shock with encephalopathy. |
| title_full_unstemmed | Azathioprine hypersensitivity presenting as septic shock with encephalopathy. |
| title_short | Azathioprine hypersensitivity presenting as septic shock with encephalopathy. |
| title_sort | azathioprine hypersensitivity presenting as septic shock with encephalopathy |
| work_keys_str_mv | AT jamesa azathioprinehypersensitivitypresentingassepticshockwithencephalopathy AT blagojevicj azathioprinehypersensitivitypresentingassepticshockwithencephalopathy AT benhams azathioprinehypersensitivitypresentingassepticshockwithencephalopathy AT cornallr azathioprinehypersensitivitypresentingassepticshockwithencephalopathy AT fraterj azathioprinehypersensitivitypresentingassepticshockwithencephalopathy |