Visual dysfunction in posterior cortical atrophy.
Posterior cortical atrophy (PCA) is a syndromic diagnosis. It is characterized by progressive impairment of higher (cortical) visual function with imaging evidence of degeneration affecting the occipital, parietal, and posterior temporal lobes bilaterally. Most cases will prove to have Alzheimer pat...
| Main Authors: | , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
Frontiers
2017
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| _version_ | 1826287710356111360 |
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| author | da Silva, M Millington, H Bridge, H James-Galton, M Plant, G |
| author_facet | da Silva, M Millington, H Bridge, H James-Galton, M Plant, G |
| author_sort | da Silva, M |
| collection | OXFORD |
| description | Posterior cortical atrophy (PCA) is a syndromic diagnosis. It is characterized by progressive impairment of higher (cortical) visual function with imaging evidence of degeneration affecting the occipital, parietal, and posterior temporal lobes bilaterally. Most cases will prove to have Alzheimer pathology. The aim of this review is to summarize the development of the concept of this disorder since it was first introduced. A critical discussion of the evolving diagnostic criteria is presented and the differential diagnosis with regard to the underlying pathology is reviewed. Emphasis is given to the visual dysfunction that defines the disorder, and the classical deficits, such as simultanagnosia and visual agnosia, as well as the more recently recognized visual field defects, are reviewed, along with the evidence on their neural correlates. The latest developments on the imaging of PCA are summarized, with special attention to its role on the differential diagnosis with related conditions. |
| first_indexed | 2024-03-07T02:02:44Z |
| format | Journal article |
| id | oxford-uuid:9debb9a0-8d7d-4d67-abfb-217d39e5f0c1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:02:44Z |
| publishDate | 2017 |
| publisher | Frontiers |
| record_format | dspace |
| spelling | oxford-uuid:9debb9a0-8d7d-4d67-abfb-217d39e5f0c12022-03-27T00:46:33ZVisual dysfunction in posterior cortical atrophy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9debb9a0-8d7d-4d67-abfb-217d39e5f0c1EnglishSymplectic Elements at OxfordFrontiers2017da Silva, MMillington, HBridge, HJames-Galton, MPlant, GPosterior cortical atrophy (PCA) is a syndromic diagnosis. It is characterized by progressive impairment of higher (cortical) visual function with imaging evidence of degeneration affecting the occipital, parietal, and posterior temporal lobes bilaterally. Most cases will prove to have Alzheimer pathology. The aim of this review is to summarize the development of the concept of this disorder since it was first introduced. A critical discussion of the evolving diagnostic criteria is presented and the differential diagnosis with regard to the underlying pathology is reviewed. Emphasis is given to the visual dysfunction that defines the disorder, and the classical deficits, such as simultanagnosia and visual agnosia, as well as the more recently recognized visual field defects, are reviewed, along with the evidence on their neural correlates. The latest developments on the imaging of PCA are summarized, with special attention to its role on the differential diagnosis with related conditions. |
| spellingShingle | da Silva, M Millington, H Bridge, H James-Galton, M Plant, G Visual dysfunction in posterior cortical atrophy. |
| title | Visual dysfunction in posterior cortical atrophy. |
| title_full | Visual dysfunction in posterior cortical atrophy. |
| title_fullStr | Visual dysfunction in posterior cortical atrophy. |
| title_full_unstemmed | Visual dysfunction in posterior cortical atrophy. |
| title_short | Visual dysfunction in posterior cortical atrophy. |
| title_sort | visual dysfunction in posterior cortical atrophy |
| work_keys_str_mv | AT dasilvam visualdysfunctioninposteriorcorticalatrophy AT millingtonh visualdysfunctioninposteriorcorticalatrophy AT bridgeh visualdysfunctioninposteriorcorticalatrophy AT jamesgaltonm visualdysfunctioninposteriorcorticalatrophy AT plantg visualdysfunctioninposteriorcorticalatrophy |