Inhibition of nonmammalian glycosidases by azetidine iminosugars derived from stable 3,5-di-O-triflates of pentoses.
Efficient ring closure of stable crystalline 3,5-di-O-triflates of pentofuranosides with amines to form azetidines allowed preliminary evaluation of four-ring iminosugars as glycosidase inhibitors; significant and specific inhibition of nonmammalian α-glucosidases is shown by L-xylo- and L-arabino-i...
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Bibliographic Details
| Main Authors: |
Lenagh-Snow, G,
Araujo, N,
Jenkinson, S,
Rutherford, C,
Nakagawa, S,
Kato, A,
Yu, C,
Weymouth-Wilson, A,
Fleet, G |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2011
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