Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A.
Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4(+)- and CD8(+)-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1797085000409022464 |
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| author | Mcshane, H Behboudi, S Goonetilleke, N Brookes, R Hill, A |
| author_facet | Mcshane, H Behboudi, S Goonetilleke, N Brookes, R Hill, A |
| author_sort | Mcshane, H |
| collection | OXFORD |
| description | Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4(+)- and CD8(+)-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by Mycobacterium bovis BCG. Following immunization with dendritic cells pulsed with an antigen 85A CD4(+)- or CD8(+)-restricted epitope, alone or in combination, copresentation of both epitopes on the same dendritic cell was required for protection, demonstrating that induced CD8(+) T cells can play a protective role against tuberculosis. |
| first_indexed | 2024-03-07T02:03:01Z |
| format | Journal article |
| id | oxford-uuid:9e02da55-e57d-4264-b154-1a2d5f24dd8a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:03:01Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:9e02da55-e57d-4264-b154-1a2d5f24dd8a2022-03-27T00:47:10ZProtective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9e02da55-e57d-4264-b154-1a2d5f24dd8aEnglishSymplectic Elements at Oxford2002Mcshane, HBehboudi, SGoonetilleke, NBrookes, RHill, AImmunization with DNA followed by modified vaccinia virus Ankara strain, both expressing the antigen 85A, induced both CD4(+)- and CD8(+)-T-cell responses in BALB/c mice. Following challenge with Mycobacterium tuberculosis, this prime-boost regimen produced protection equivalent to that conferred by Mycobacterium bovis BCG. Following immunization with dendritic cells pulsed with an antigen 85A CD4(+)- or CD8(+)-restricted epitope, alone or in combination, copresentation of both epitopes on the same dendritic cell was required for protection, demonstrating that induced CD8(+) T cells can play a protective role against tuberculosis. |
| spellingShingle | Mcshane, H Behboudi, S Goonetilleke, N Brookes, R Hill, A Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A. |
| title | Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A. |
| title_full | Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A. |
| title_fullStr | Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A. |
| title_full_unstemmed | Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A. |
| title_short | Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A. |
| title_sort | protective immunity against mycobacterium tuberculosis induced by dendritic cells pulsed with both cd8 and cd4 t cell epitopes from antigen 85a |
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