Glycoprotein synthesis: From glycobiological tools to tailor-made catalysts
The synthesis of pure, well-defined glycoproteins is essential to the study of the host of biological processes that they mediate. The use of a combined site-directed mutagenesis and chemical modification strategy allows the site-selective synthesis of homogenous glycoproteins, the determination of...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Georg Thieme Verlag
1999
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| Summary: | The synthesis of pure, well-defined glycoproteins is essential to the study of the host of biological processes that they mediate. The use of a combined site-directed mutagenesis and chemical modification strategy allows the site-selective synthesis of homogenous glycoproteins, the determination of precise structure-activity relationships and the design of new synthetic catalysts. This general and powerful method is reviewed in the context of existing preparative techniques and the wide-ranging applications of glycoproteins are highlighted. |
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