Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections.
Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1826287772146597888 |
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| author | Tan, L van Doorn, H Nghia, H Chau, T Tu, L de Vries, M Canuti, M Deijs, M Jebbink, M Baker, S Bryant, J Tham, N BKrong, N Boni, M Loi, T Phuong, LT Verhoeven, J Crusat, M Jeeninga, R Schultsz, C Chau, N Hien, T van der Hoek, L Farrar, J Jong, d |
| author_facet | Tan, L van Doorn, H Nghia, H Chau, T Tu, L de Vries, M Canuti, M Deijs, M Jebbink, M Baker, S Bryant, J Tham, N BKrong, N Boni, M Loi, T Phuong, LT Verhoeven, J Crusat, M Jeeninga, R Schultsz, C Chau, N Hien, T van der Hoek, L Farrar, J Jong, d |
| author_sort | Tan, L |
| collection | OXFORD |
| description | Acute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus. |
| first_indexed | 2024-03-07T02:03:40Z |
| format | Journal article |
| id | oxford-uuid:9e3c235c-cb62-4f9f-9326-b2a68ac629de |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:03:40Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:9e3c235c-cb62-4f9f-9326-b2a68ac629de2022-03-27T00:48:40ZIdentification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9e3c235c-cb62-4f9f-9326-b2a68ac629deEnglishSymplectic Elements at Oxford2013Tan, Lvan Doorn, HNghia, HChau, TTu, Lde Vries, MCanuti, MDeijs, MJebbink, MBaker, SBryant, JTham, NBKrong, NBoni, MLoi, TPhuong, LTVerhoeven, JCrusat, MJeeninga, RSchultsz, CChau, NHien, Tvan der Hoek, LFarrar, JJong, dAcute central nervous system (CNS) infections cause substantial morbidity and mortality, but the etiology remains unknown in a large proportion of cases. We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. CyCV-VN was subsequently detected in 4% of 642 CSF specimens from Vietnamese patients with suspected CNS infections and none of 122 CSFs from patients with noninfectious neurological disorders. Detection rates were similar in patients with CNS infections of unknown etiology and those in whom other pathogens were detected. A similar detection rate in feces from healthy children suggested food-borne or orofecal transmission routes, while high detection rates in feces from pigs and poultry (average, 58%) suggested the existence of animal reservoirs for such transmission. Further research is needed to address the epidemiology and pathogenicity of this novel, potentially zoonotic virus. |
| spellingShingle | Tan, L van Doorn, H Nghia, H Chau, T Tu, L de Vries, M Canuti, M Deijs, M Jebbink, M Baker, S Bryant, J Tham, N BKrong, N Boni, M Loi, T Phuong, LT Verhoeven, J Crusat, M Jeeninga, R Schultsz, C Chau, N Hien, T van der Hoek, L Farrar, J Jong, d Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. |
| title | Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. |
| title_full | Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. |
| title_fullStr | Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. |
| title_full_unstemmed | Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. |
| title_short | Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. |
| title_sort | identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections |
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