A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus
Experimental and epidemiological data suggest that factors of one-carbon metabolism are important in the pathogenesis of several cancers, but prospective data on head and neck cancer (HNC) and esophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Wiley-Liss Inc.
2015
|
| _version_ | 1826287780792107008 |
|---|---|
| author | Fanidi, A Relton, C Ueland, P Midttun, Ø Vollset, SE Travis, R Trichopoulou, A Lagiou, P Trichopoulos, D Bueno-De-Mesquita, H Ros, M Boeing, H Tumino, R Panico, S Palli, D Sieri, S Vineis, P Sánchez, M Huerta, J Gurrea, AB Luján-Barroso, L Quirós, JR Tjønneland, A Halkjær, J Boutron-Ruault, M |
| author_facet | Fanidi, A Relton, C Ueland, P Midttun, Ø Vollset, SE Travis, R Trichopoulou, A Lagiou, P Trichopoulos, D Bueno-De-Mesquita, H Ros, M Boeing, H Tumino, R Panico, S Palli, D Sieri, S Vineis, P Sánchez, M Huerta, J Gurrea, AB Luján-Barroso, L Quirós, JR Tjønneland, A Halkjær, J Boutron-Ruault, M |
| author_sort | Fanidi, A |
| collection | OXFORD |
| description | Experimental and epidemiological data suggest that factors of one-carbon metabolism are important in the pathogenesis of several cancers, but prospective data on head and neck cancer (HNC) and esophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants from 10 countries who donated a blood sample. The current study included 516 cancer cases of the head and neck and esophagus and 516 individually matched controls. Plasma levels of vitamins B2, B6, B9 (folate), B12, and methionine and homocysteine were measured in pre-diagnostic plasma samples and analyzed in relation to HNC and esophagus cancer risk, as well as post-diagnosis all-cause mortality. After controlling for risk factors, study participants with higher levels of homocysteine had elevated risk of HNC, the odds ratio (OR) in conditional analysis when comparing the top and bottom quartiles of homocysteine [ORQ4 vs. Q1] being 2.13 (95% confidence interval [95% CI] 1.13-4.00, p for trend 0.009). A slight decrease in HNC risk was also seen among subjects with higher levels of folate (ORQ4 vs. Q1 0.63, 95% CI 0.35-1.16, p for trend 0.02). Subgroup analyses by anatomical sub-site indicated particularly strong associations with circulating homocysteine for oral cavity and gum cancer (p for trend 8 × 10-4), as well as for oropharynx cancer (p for trend 0.008). Plasma concentrations of the other investigated biomarkers did not display any clear association with risk or survival. In conclusion, study participants with elevated circulating levels of homocysteine had increased risk of developing squamous cell carcinoma of the head and neck. |
| first_indexed | 2024-03-07T02:03:47Z |
| format | Journal article |
| id | oxford-uuid:9e447b02-db20-47d9-b329-3ab6f57f70e9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:03:47Z |
| publishDate | 2015 |
| publisher | Wiley-Liss Inc. |
| record_format | dspace |
| spelling | oxford-uuid:9e447b02-db20-47d9-b329-3ab6f57f70e92022-03-27T00:48:58ZA prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9e447b02-db20-47d9-b329-3ab6f57f70e9EnglishSymplectic Elements at OxfordWiley-Liss Inc.2015Fanidi, ARelton, CUeland, PMidttun, ØVollset, SETravis, RTrichopoulou, ALagiou, PTrichopoulos, DBueno-De-Mesquita, HRos, MBoeing, HTumino, RPanico, SPalli, DSieri, SVineis, PSánchez, MHuerta, JGurrea, ABLuján-Barroso, LQuirós, JRTjønneland, AHalkjær, JBoutron-Ruault, MExperimental and epidemiological data suggest that factors of one-carbon metabolism are important in the pathogenesis of several cancers, but prospective data on head and neck cancer (HNC) and esophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants from 10 countries who donated a blood sample. The current study included 516 cancer cases of the head and neck and esophagus and 516 individually matched controls. Plasma levels of vitamins B2, B6, B9 (folate), B12, and methionine and homocysteine were measured in pre-diagnostic plasma samples and analyzed in relation to HNC and esophagus cancer risk, as well as post-diagnosis all-cause mortality. After controlling for risk factors, study participants with higher levels of homocysteine had elevated risk of HNC, the odds ratio (OR) in conditional analysis when comparing the top and bottom quartiles of homocysteine [ORQ4 vs. Q1] being 2.13 (95% confidence interval [95% CI] 1.13-4.00, p for trend 0.009). A slight decrease in HNC risk was also seen among subjects with higher levels of folate (ORQ4 vs. Q1 0.63, 95% CI 0.35-1.16, p for trend 0.02). Subgroup analyses by anatomical sub-site indicated particularly strong associations with circulating homocysteine for oral cavity and gum cancer (p for trend 8 × 10-4), as well as for oropharynx cancer (p for trend 0.008). Plasma concentrations of the other investigated biomarkers did not display any clear association with risk or survival. In conclusion, study participants with elevated circulating levels of homocysteine had increased risk of developing squamous cell carcinoma of the head and neck. |
| spellingShingle | Fanidi, A Relton, C Ueland, P Midttun, Ø Vollset, SE Travis, R Trichopoulou, A Lagiou, P Trichopoulos, D Bueno-De-Mesquita, H Ros, M Boeing, H Tumino, R Panico, S Palli, D Sieri, S Vineis, P Sánchez, M Huerta, J Gurrea, AB Luján-Barroso, L Quirós, JR Tjønneland, A Halkjær, J Boutron-Ruault, M A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus |
| title | A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus |
| title_full | A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus |
| title_fullStr | A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus |
| title_full_unstemmed | A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus |
| title_short | A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus |
| title_sort | prospective study of one carbon metabolism biomarkers and cancer of the head and neck and esophagus |
| work_keys_str_mv | AT fanidia aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT reltonc aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT uelandp aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT midttunø aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT vollsetse aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT travisr aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT trichopouloua aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT lagioup aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT trichopoulosd aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT buenodemesquitah aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT rosm aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT boeingh aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT tuminor aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT panicos aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT pallid aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT sieris aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT vineisp aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT sanchezm aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT huertaj aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT gurreaab aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT lujanbarrosol aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT quirosjr aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT tjønnelanda aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT halkjærj aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT boutronruaultm aprospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT fanidia prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT reltonc prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT uelandp prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT midttunø prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT vollsetse prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT travisr prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT trichopouloua prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT lagioup prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT trichopoulosd prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT buenodemesquitah prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT rosm prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT boeingh prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT tuminor prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT panicos prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT pallid prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT sieris prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT vineisp prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT sanchezm prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT huertaj prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT gurreaab prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT lujanbarrosol prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT quirosjr prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT tjønnelanda prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT halkjærj prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus AT boutronruaultm prospectivestudyofonecarbonmetabolismbiomarkersandcanceroftheheadandneckandesophagus |