Out of the box binding determines specificity of SH2 domain interaction.
SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| Subjects: |
| _version_ | 1826287781200003072 |
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| author | Müller, S Knapp, S |
| author_facet | Müller, S Knapp, S |
| author_sort | Müller, S |
| collection | OXFORD |
| description | SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket. |
| first_indexed | 2024-03-07T02:03:47Z |
| format | Journal article |
| id | oxford-uuid:9e44c8eb-cebd-4ee3-be17-b9498c77b91f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:03:47Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:9e44c8eb-cebd-4ee3-be17-b9498c77b91f2022-03-27T00:48:55ZOut of the box binding determines specificity of SH2 domain interaction.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9e44c8eb-cebd-4ee3-be17-b9498c77b91fmetabolismProtein BindingSignal TransductionBinding SiteschemistryPhosphotyrosinegeneticssrc Homology DomainsMutationEnglishStructural Genomics Consortium2009Müller, SKnapp, SSH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket. |
| spellingShingle | metabolism Protein Binding Signal Transduction Binding Sites chemistry Phosphotyrosine genetics src Homology Domains Mutation Müller, S Knapp, S Out of the box binding determines specificity of SH2 domain interaction. |
| title | Out of the box binding determines specificity of SH2 domain interaction. |
| title_full | Out of the box binding determines specificity of SH2 domain interaction. |
| title_fullStr | Out of the box binding determines specificity of SH2 domain interaction. |
| title_full_unstemmed | Out of the box binding determines specificity of SH2 domain interaction. |
| title_short | Out of the box binding determines specificity of SH2 domain interaction. |
| title_sort | out of the box binding determines specificity of sh2 domain interaction |
| topic | metabolism Protein Binding Signal Transduction Binding Sites chemistry Phosphotyrosine genetics src Homology Domains Mutation |
| work_keys_str_mv | AT mullers outoftheboxbindingdeterminesspecificityofsh2domaininteraction AT knapps outoftheboxbindingdeterminesspecificityofsh2domaininteraction |