Out of the box binding determines specificity of SH2 domain interaction.
SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| Subjects: |