Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in several populations; the rat homolog has been directly implicated in diabetes susceptibility; and kno...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Groves, C, Wiltshire, S, Smedley, D, Owen, K, Frayling, T, Walker, M, Hitman, G, Levy, J, O'Rahilly, S, Menzel, S, Hattersley, A, McCarthy, M
التنسيق:	Journal article
اللغة:	English
منشور في:	2003

مواد مشابهة

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.
حسب: Frayling, T, وآخرون
منشور في: (2000)

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
حسب: Groves, C, وآخرون
منشور في: (2006)

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
حسب: Wiltshire, S, وآخرون
منشور في: (2002)

Linkage studies of the Type 2 diabetes susceptibility locus on chromosome 1q: Combined analysis of 1200 UK and French affected sibpairs
حسب: Groves, C, وآخرون
منشور في: (2002)

Linkage analysis in the Diabetes (UK) Warren 2 sibpair repository supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-24.
حسب: McCarthy, M, وآخرون
منشور في: (2001)

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
حسب: Liew, C, وآخرون
منشور في: (2004)

Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.
حسب: Zeggini, E, وآخرون
منشور في: (2005)

High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people.
حسب: Florez, J, وآخرون
منشور في: (2006)

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
حسب: Frayling, T, وآخرون
منشور في: (2003)

Type 2 diabetes and the human homolog of the rat insulin resistance gene, CD36: No linkage or association in Europeans
حسب: McCarthy, M, وآخرون
منشور في: (1999)

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
حسب: Huxtable, S, وآخرون
منشور في: (2000)

Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
حسب: Zeggini, E, وآخرون
منشور في: (2004)

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
حسب: Owen, K, وآخرون
منشور في: (2006)

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
حسب: Wiltshire, S, وآخرون
منشور في: (2004)

The BDA Warren Type 2 Diabetes Sibpair Repository: Susceptibility regions identified by genome scan of 439 European families
حسب: McCarthy, M, وآخرون
منشور في: (2000)

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
حسب: Owen, K, وآخرون
منشور في: (2004)

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
حسب: Desai, M, وآخرون
منشور في: (2006)

Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.
حسب: Mills, G, وآخرون
منشور في: (2004)

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
حسب: Groves, C, وآخرون
منشور في: (2006)

Insulin resistance : insulin action and its disturbances in disease /
حسب: Kumar, Sudhesh, وآخرون
منشور في: (2005)

Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.
حسب: Wiltshire, S, وآخرون
منشور في: (2006)

Susceptibility for latent autoimmune diabetes in adults (LADA) is determined by variation at the 1DDM2 (insulin-gene) locus in white Caucasian patients from UK repositories
حسب: Desai, M, وآخرون
منشور في: (2005)

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.
حسب: Wiltshire, S, وآخرون
منشور في: (2001)

Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus.
حسب: Bell, C, وآخرون
منشور في: (2010)

Susceptibility effects of variation at the IDDM2 (Insulin-gene) locus in latent autoimmune diabetes in adults (LADA).
حسب: Desai, M, وآخرون
منشور في: (2003)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to Type 2 diabetes
حسب: Jafar-Mohammadi, B, وآخرون
منشور في: (2009)

Low frequency variants in the exons only encoding isoform A of HNF1A do not contribute to susceptibility to type 2 diabetes.
حسب: Jafar-Mohammadi, B, وآخرون
منشور في: (2009)

Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKALI and HHEX-IDE gene loci reduce birth weight
حسب: Hattersley, A, وآخرون
منشور في: (2008)

Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.
حسب: O'Rahilly, S, وآخرون
منشور في: (1988)

Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease
حسب: Belbin, O, وآخرون
منشور في: (2010)

Role of low frequency variants in HNF1A exons 8-10 encoding hepatocyte nuclear factor-1 alpha isoform A to susceptibility to Type 2 diabetes
حسب: Jafar-Mohammadi, B, وآخرون
منشور في: (2010)

Application of structural model of glucose-insulin relations to assess beta-cell function and insulin sensitivity.
حسب: Turner, R, وآخرون
منشور في: (1990)

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
حسب: Zeggini, E, وآخرون
منشور في: (2004)

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
حسب: Edghill, E, وآخرون
منشور في: (2011)

Pathogenesis of NIDDM--a disease of deficient insulin secretion.
حسب: Turner, R, وآخرون
منشور في: (1988)

Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach
حسب: Gloyn, A, وآخرون
منشور في: (2005)

New methods for finding disease-susceptibility genes: impact and potential.
حسب: McCarthy, M, وآخرون
منشور في: (2003)

Genome-wide search for multiple loci in type 2 diabetes
حسب: Bell, J, وآخرون
منشور في: (2007)

Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes
حسب: Groves, C, وآخرون
منشور في: (2006)

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
حسب: Patel, S, وآخرون
منشور في: (2006)