Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.

The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in several populations; the rat homolog has been directly implicated in diabetes susceptibility; and kno...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Groves, C, Wiltshire, S, Smedley, D, Owen, K, Frayling, T, Walker, M, Hitman, G, Levy, J, O'Rahilly, S, Menzel, S, Hattersley, A, McCarthy, M
פורמט:	Journal article
שפה:	English
יצא לאור:	2003

פריטים דומים

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Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
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יצא לאור: (2002)

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יצא לאור: (2002)

Linkage analysis in the Diabetes (UK) Warren 2 sibpair repository supports localisation of a type 2 diabetes susceptibility gene to chromosome 1q21-24.
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Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
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יצא לאור: (2003)

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Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKALI and HHEX-IDE gene loci reduce birth weight
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