High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions.
Maturation of Plasmodium falciparum decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of Plasmodium vivax-infected RBCs led to opposite conclusions with respect to cellul...
| Asıl Yazarlar: | , , , , , , , , , , |
|---|---|
| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
2009
|
| _version_ | 1826287802184105984 |
|---|---|
| author | Handayani, S Chiu, D Tjitra, E Kuo, J Lampah, D Kenangalem, E Renia, L Snounou, G Price, R Anstey, N Russell, B |
| author_facet | Handayani, S Chiu, D Tjitra, E Kuo, J Lampah, D Kenangalem, E Renia, L Snounou, G Price, R Anstey, N Russell, B |
| author_sort | Handayani, S |
| collection | OXFORD |
| description | Maturation of Plasmodium falciparum decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of Plasmodium vivax-infected RBCs led to opposite conclusions with respect to cellular deformability. To resolve this controversy, P. vivax-infected RBCs were passed through a 2-microm microfluidic channel. In contrast to P. falciparum-infected RBCs, mature P. vivax-infected RBCs readily became deformed through 2-microm constrictions. After this extreme deformation, 67% of P. vivax-infected RBCs recovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria. |
| first_indexed | 2024-03-07T02:04:07Z |
| format | Journal article |
| id | oxford-uuid:9e5e62b1-46b6-41d9-9e40-1b660eb653a7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:04:07Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:9e5e62b1-46b6-41d9-9e40-1b660eb653a72022-03-27T00:49:40ZHigh deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9e5e62b1-46b6-41d9-9e40-1b660eb653a7EnglishSymplectic Elements at Oxford2009Handayani, SChiu, DTjitra, EKuo, JLampah, DKenangalem, ERenia, LSnounou, GPrice, RAnstey, NRussell, BMaturation of Plasmodium falciparum decreases the deformability of infected red blood cells (RBCs), increasing their clearance as they attempt to pass through endothelial slits of the splenic sinus. Previous studies of Plasmodium vivax-infected RBCs led to opposite conclusions with respect to cellular deformability. To resolve this controversy, P. vivax-infected RBCs were passed through a 2-microm microfluidic channel. In contrast to P. falciparum-infected RBCs, mature P. vivax-infected RBCs readily became deformed through 2-microm constrictions. After this extreme deformation, 67% of P. vivax-infected RBCs recovered a normal appearance; however, 15% of uninfected RBCs were destroyed. Results suggest mechanisms for both avoidance of splenic clearance and anemia in vivax malaria. |
| spellingShingle | Handayani, S Chiu, D Tjitra, E Kuo, J Lampah, D Kenangalem, E Renia, L Snounou, G Price, R Anstey, N Russell, B High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. |
| title | High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. |
| title_full | High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. |
| title_fullStr | High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. |
| title_full_unstemmed | High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. |
| title_short | High deformability of Plasmodium vivax-infected red blood cells under microfluidic conditions. |
| title_sort | high deformability of plasmodium vivax infected red blood cells under microfluidic conditions |
| work_keys_str_mv | AT handayanis highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT chiud highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT tjitrae highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT kuoj highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT lampahd highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT kenangaleme highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT renial highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT snounoug highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT pricer highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT ansteyn highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions AT russellb highdeformabilityofplasmodiumvivaxinfectedredbloodcellsundermicrofluidicconditions |