Autophagy and immune senescence
With extension of the average lifespan, aging has become a heavy burden in society. Immune senescence is a key risk factor for many age-related diseases such as cancer and increased infections in the elderly, and hence has elicited much attention in recent years. As our body's guardian, the imm...
| Principais autores: | , , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Cell Press
2016
|
| _version_ | 1826287813636653056 |
|---|---|
| author | Zhang, H Puleston, D Simon, A |
| author_facet | Zhang, H Puleston, D Simon, A |
| author_sort | Zhang, H |
| collection | OXFORD |
| description | With extension of the average lifespan, aging has become a heavy burden in society. Immune senescence is a key risk factor for many age-related diseases such as cancer and increased infections in the elderly, and hence has elicited much attention in recent years. As our body's guardian, the immune system maintains systemic health through removal of pathogens and damage. Autophagy is an important cellular 'clearance' process by which a cell internally delivers damaged organelles and macromolecules to lysosomes for degradation. Here, we discuss the most current knowledge of how impaired autophagy can lead to cellular and immune senescence. We also provide an overview, with examples, of the clinical potential of exploiting autophagy to delay immune senescence and/or rejuvenate immunity to treat various age-related diseases. |
| first_indexed | 2024-03-07T02:04:17Z |
| format | Journal article |
| id | oxford-uuid:9e6ec8b0-eb6d-4f67-b1a4-2cab11fb1ab4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:04:17Z |
| publishDate | 2016 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:9e6ec8b0-eb6d-4f67-b1a4-2cab11fb1ab42022-03-27T00:50:06ZAutophagy and immune senescenceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9e6ec8b0-eb6d-4f67-b1a4-2cab11fb1ab4EnglishSymplectic Elements at OxfordCell Press2016Zhang, HPuleston, DSimon, AWith extension of the average lifespan, aging has become a heavy burden in society. Immune senescence is a key risk factor for many age-related diseases such as cancer and increased infections in the elderly, and hence has elicited much attention in recent years. As our body's guardian, the immune system maintains systemic health through removal of pathogens and damage. Autophagy is an important cellular 'clearance' process by which a cell internally delivers damaged organelles and macromolecules to lysosomes for degradation. Here, we discuss the most current knowledge of how impaired autophagy can lead to cellular and immune senescence. We also provide an overview, with examples, of the clinical potential of exploiting autophagy to delay immune senescence and/or rejuvenate immunity to treat various age-related diseases. |
| spellingShingle | Zhang, H Puleston, D Simon, A Autophagy and immune senescence |
| title | Autophagy and immune senescence |
| title_full | Autophagy and immune senescence |
| title_fullStr | Autophagy and immune senescence |
| title_full_unstemmed | Autophagy and immune senescence |
| title_short | Autophagy and immune senescence |
| title_sort | autophagy and immune senescence |
| work_keys_str_mv | AT zhangh autophagyandimmunesenescence AT pulestond autophagyandimmunesenescence AT simona autophagyandimmunesenescence |